Molecule Information

General Information of the Molecule (ID: Mol02177)
Name
Non-coding RNA activated by DNA damage (NORAD) ,Homo sapiens
Synonyms
NORAD
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Molecule Type
LncRNA
Gene Name
NORAD
Gene ID
647979
Location
chr20:36,045,618-36,051,018[-]
Ensembl ID
ENSG00000260032
HGNC ID
HGNC:44311
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Investigative Drug(s)
1 drug(s) in total
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Cyperquat
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Parkinson disease [1]
Resistant Disease Parkinson disease [ICD-11: 8A00.0]
 Disease Info 
Resistant Drug Cyperquat
 Drug Info 
Molecule Alteration Down-regulation
Expression
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model SH-SY5Y cells Abdomen Homo sapiens (Human) CVCL_0019
Experiment for
Molecule Alteration		 qRT-PCR
Experiment for
Drug Resistance		 XTT assay; TUNEL assay; caspase 3/7 activity fluorescence measurement; Total Reactive Oxygen Species assay; Pierce LDH Cytotoxicity assay
Mechanism Description NORAD downregulation was found to significantly deteriorate MPP+-induced cytotoxicity in SH-SY5Y cells.
References
Ref 1 Long noncoding RNA NORAD regulates MPP+-induced Parkinson's disease model cellsJ Chem Neuroanat. 2019 Nov;101:101668. doi: 10.1016/j.jchemneu.2019.101668. Epub 2019 Aug 14.

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