Drug Information

Drug (ID: DG01798) and It's Reported Resistant Information

• Name: Cyperquat
• Synonyms: Cyperquat; MPP+; 1-METHYL-4-PHENYLPYRIDINIUM; N-Methyl-4-phenylpyridine; 48134-75-4; N-Methyl-4-phenylpyridinium ion; 1-methyl-4-phenylpyridin-1-ium; N-Methyl-4-phenylpyridinium; Pyridinium,1-methyl-4-phenyl-; UNII-R865A5OY8J; CHEBI:641; R865A5OY8J; Cyperquat [ANSI]; Pyridinium, 1-methyl-4-phenyl-; 1 Methyl 4 Phenylpyridinium; CCRIS 2187; BRN 1618932; Cyperquat [ANSI:ISO]; SCHEMBL37321; CHEMBL311617; GTPL4568; DTXSID4058106; BDBM81945; ZINC967769; CAS_39484; NSC_39484; Pyridinium, 1-methyl-4-phenyl- (9CI); 5-20-07-00550 (Beilstein Handbook Reference); Q161645
• Indication:
  In total 1 Indication(s)
  Discovery agent [ICD-11: N.A.]; Investigative; [1]
• Drug Resistance Disease(s):
  Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases)
  Parkinson disease [ICD-11: 8A00]; [1]
• Target: .; NOUNIPROTAC; [1]
• Formula: 1
• IsoSMILES: C[N+]1=CC=C(C=C1)C2=CC=CC=C2
• InChI: InChI=1S/C12H12N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-10H,1H3/q+1
• InChIKey: FMGYKKMPNATWHP-UHFFFAOYSA-N
• PubChem CID: 39484
• ChEBI ID: CHEBI:641
• TTD Drug ID: D09HLX
• INTEDE ID: DR01488

Type(s) of Resistant Mechanism of This Drug

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-08: Nervous system diseases

Parkinson disease [ICD-11: 8A00]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Non-coding RNA activated by DNA damage (NORAD) [1]

• Molecule Alteration: Down-regulation; Expression
• Resistant Disease: Parkinson disease [ICD-11: 8A00.0]
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: SH-SY5Y cells; Abdomen; Homo sapiens (Human); CVCL_0019
• Experiment for Molecule Alteration: qRT-PCR
• Experiment for Drug Resistance: XTT assay; TUNEL assay; caspase 3/7 activity fluorescence measurement; Total Reactive Oxygen Species assay; Pierce LDH Cytotoxicity assay
• Mechanism Description: NORAD downregulation was found to significantly deteriorate MPP+-induced cytotoxicity in SH-SY5Y cells.

Key Molecule: Nuclear paraspeckle assembly transcript 1 (NEAT1) [2]

• Molecule Alteration: Up-regulation; Interaction
• Resistant Disease: Parkinson disease [ICD-11: 8A00.0]
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: SH-SY6Y cells; N.A.; .; N.A.
• Experiment for Molecule Alteration: Mimic assay; qRT-PCR; RNA pull down assay; RIP experiments assay; ELISA assay; Knockdown assay
• Experiment for Drug Resistance: MTT assay; Flow cytometry assay
• Mechanism Description: NEAT1 may regulate MPP+ induced neuronal injury by targeting miR-124 in SH-SY5Y cells.

References

• Ref 1: Long noncoding RNA NORAD regulates MPP+-induced Parkinson's disease model cellsJ Chem Neuroanat. 2019 Nov;101:101668. doi: 10.1016/j.jchemneu.2019.101668. Epub 2019 Aug 14.
• Ref 2: NEAT1 regulates MPP(+)-induced neuronal injury by targeting miR-124 in neuroblastoma cellsNeurosci Lett. 2019 Aug 24;708:134340. doi: 10.1016/j.neulet.2019.134340. Epub 2019 Jun 19.