Molecule Information

General Information of the Molecule (ID: Mol02162)

• Name: Small nucleolar RNA host gene 14 (SNHG14) ,Mus musculus
• Synonyms: Snhg14
• Molecule Type: LncRNA
• Gene Name: Snhg14
• Gene ID: 52480

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Rotenone

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Parkinson disease [1]

• Resistant Disease: Parkinson disease [ICD-11: 8A00.0]
• Resistant Drug: Rotenone
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: SNHG14/miR-133b/alpha -syn signaling pathway; Inhibition; hsa04933
• In Vitro Model: MN9D cells; N.A.; Mus musculus (Mouse); CVCL_M067
• In Vivo Model: C57BL/6 mice xenograft model; Mus musculus
• Experiment for Molecule Alteration: Knockdown assay
• Experiment for Drug Resistance: Motor function assessment assay; CCK8 assay; ROS staining and detection assay
• Mechanism Description: Silence of SNHG14 mitigates dopaminergic neuron injury by down-regulating alpha-syn via targeting miR-133b, which contributes to improving PD.

References

• Ref 1: Dopaminergic neuron injury in Parkinson's disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ Alpha-synuclein pathwayAging (Albany NY). 2019 Nov 4;11(21):9264-9279. doi: 10.18632/aging.102330. Epub 2019 Nov 4.