Molecule Information

General Information of the Molecule (ID: Mol02154)

• Name: MX dynamin like GTPase 1 (MX1) ,Homo sapiens
• Synonyms: MX1
• Molecule Type: LncRNA
• Gene Name: MX1
• Gene ID: 4599
• Location: chr21:41,420,020-41,470,071[+]
• Ensembl ID: ENSG00000157601
• HGNC ID: HGNC:7532

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Interferon alfa-2B

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Head and neck squamous cell carcinoma [1]

• Resistant Disease: Head and neck squamous cell carcinoma [ICD-11: 2D42.1]
• Resistant Drug: Interferon alfa-2B
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: HN30 cells; Nasopharyngeal; Homo sapiens (Human); CVCL_5525
• In Vitro Model: HN4 cells; Nasopharyngeal; Homo sapiens (Human); CVCL_IS30
• In Vitro Model: HN6 cells; Tongue; Homo sapiens (Human); CVCL_8129
• In Vivo Model: BALB/c nude mice model; Mus musculus
• Experiment for Molecule Alteration: Overexpression assay
• Experiment for Drug Resistance: Flow cytometry assay
• Mechanism Description: LncMX1-215 negatively regulates immunosuppression by interrupting GCN5/H3K27ac binding in HNSCC.

References

• Ref 1: A novel IFNAlpha-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinomaMol Cancer. 2020 Jan 6;19(1):4. doi: 10.1186/s12943-019-1123-y.