Drug Information

Drug (ID: DG01848) and It's Reported Resistant Information

Name	Interferon alfa-2B
Synonyms	INTERFERON ALFA-2B; 98530-12-2; Interferon alfa-2b, recombinant; C16H17Cl3I2N3NaO5S; SCHEMBL6041041; K779; Q4391540 Click to Show/Hide
Indication	In total 1 Indication(s) Melanoma [ICD-11: 2C30] Approved [1]
Structure
Drug Resistance Disease(s)	Disease(s) with Clinically Reported Resistance for This Drug (1 diseases) Head and neck cancer [ICD-11: 2D42] [1]
Target	Interferon-alpha 2 (IFNA2)	IFNA2_HUMAN	[1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula	7
IsoSMILES	CCCN(CCOC1=C(C=C(C=C1Cl)Cl)Cl)C(=O)N2C=CN=C2.C(S(=O)(=O)[O-])(I)I.[Na+]
InChI	InChI=1S/C15H16Cl3N3O2.CH2I2O3S.Na/c1-2-4-20(15(22)21-5-3-19-10-21)6-7-23-14-12(17)8-11(16)9-13(14)18;2-1(3)7(4,5)6;/h3,5,8-10H,2,4,6-7H2,1H3;1H,(H,4,5,6);/q;;+1/p-1
InChIKey	MIXCUJKCXRNYFM-UHFFFAOYSA-M
PubChem CID	71306834
TTD Drug ID	D0P0WV
DrugBank ID	DB05258

Type(s) of Resistant Mechanism of This Drug

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Click to Show/Hide the Resistance Disease of This Class

Head and neck cancer [ICD-11: 2D42]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: MX dynamin like GTPase 1 (MX1)				[1]
Molecule Alteration	Up-regulation		Interaction	Molecule Info
Resistant Disease	Head and neck squamous cell carcinoma [ICD-11: 2D42.1]			Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	HN30 cells	Nasopharyngeal	Homo sapiens (Human)	CVCL_5525
	HN4 cells	Nasopharyngeal	Homo sapiens (Human)	CVCL_IS30
	HN6 cells	Tongue	Homo sapiens (Human)	CVCL_8129
In Vivo Model	BALB/c nude mice model			Mus musculus
Experiment for Molecule Alteration	Overexpression assay
Experiment for Drug Resistance	Flow cytometry assay
Mechanism Description	LncMX1-215 negatively regulates immunosuppression by interrupting GCN5/H3K27ac binding in HNSCC.

References

Ref 1	A novel IFNAlpha-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinomaMol Cancer. 2020 Jan 6;19(1):4. doi: 10.1186/s12943-019-1123-y.