Molecule Information

General Information of the Molecule (ID: Mol02152)
Name
hsa_circRNA_0000309 ,Homo sapiens
Synonyms
hsa_circRNA_0000309
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Molecule Type
Circular RNA
Gene Name
hsa_circRNA_0000309
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Investigative Drug(s)
1 drug(s) in total
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Germacrone
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Diabetic nephropathy [1]
Resistant Disease Diabetic nephropathy [ICD-11: GB61.Z]
 Disease Info 
Resistant Drug Germacrone
 Drug Info 
Molecule Alteration Expression
Down-regulation
Experimental Note Discovered Using In-vivo Testing Model
In Vitro Model MPC5 cells Kidney Mus musculus (Mouse) CVCL_AS87
In Vivo Model C57BL/6J mouse model; C57BL/KsJ mouse model; db/db mice mouse model Mus musculus
Experiment for
Molecule Alteration		 qRT-PCR
Mechanism Description Mmu_circRNA_0000309 silence mediates drug resistance to germacrone in DN mice. mmu_circRNA_0000309 sponges miR-188-3p, and subsequently upregulates GPX4 expression, inactivating ferroptosis-dependent mitochondrial function and podocyte apoptosis.
Disease Class: Diabetic nephropathy [1]
Resistant Disease Diabetic nephropathy [ICD-11: GB61.Z]
 Disease Info 
Resistant Drug Germacrone
 Drug Info 
Molecule Alteration Expression
Down-regulation
Experimental Note Discovered Using In-vivo Testing Model
In Vitro Model MPC5 cells Kidney Mus musculus (Mouse) CVCL_AS87
In Vivo Model C57BL/6J mouse model; C57BL/KsJ mouse model; db/db mice mouse model Mus musculus
Experiment for
Molecule Alteration		 qRT-PCR
Mechanism Description Mmu_circRNA_0000309 silence mediates drug resistance to germacrone in DN mice. mmu_circRNA_0000309 sponges miR-188-3p, and subsequently upregulates GPX4 expression, inactivating ferroptosis-dependent mitochondrial function and podocyte apoptosis.
References
Ref 1 A Novel Identified Circular RNA, mmu_mmu_circRNA_0000309, Involves in Germacrone-Mediated Improvement of Diabetic Nephropathy Through Regulating Ferroptosis by Targeting miR-188-3p/GPX4 Signaling Axis .Antioxid Redox Signal. 2022 Apr;36(10-12):740-759. doi: 10.1089/ars.2021.0063. 10.1089/ars.2021.0063

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