Drug Information

Drug (ID: DG00616) and It's Reported Resistant Information

• Name: Germacrone
• Synonyms: Germacrone; 6902-91-6; (3E,7E)-3,7-Dimethyl-10-(propan-2-ylidene)cyclodeca-3,7-dienone; Germacron; (3E,7E)-3,7-dimethyl-10-propan-2-ylidenecyclodeca-3,7-dien-1-one; Germacrone,(S); Germacrol (obsol;); UNII-E2WQ6N4FBP; E2WQ6N4FBP; Germacrone, analytical standard; SCHEMBL2551615; SCHEMBL14215872; CHEBI:80830; HY-N0440; MFCD00210050; s9311; ZINC31308583; AKOS016009673; CCG-266711; NCGC00482596-01; AC-34324; CS-0008961; G0519; N1500; V0249; (E,E)-Germacra-3,7(11),9-trien-6-one; C16966; 902G916; Q-100776; Q15410959; trans,trans-3,7-dimethyl-10-isopropylidene-3,7-cyclodecadien-1-one
• Drug Resistance Disease(s):
  Disease(s) with Resistance Information Validated by in-vivo Model for This Drug (1 diseases)
  Chronic kidney disease [ICD-11: GB61]; [1]
• Target: .; NOUNIPROTAC; [1]
• Formula: C15H22O
• IsoSMILES: C/C/1=C\\CC(=C(C)C)C(=O)C/C(=C/CC1)/C
• InChI: 1S/C15H22O/c1-11(2)14-9-8-12(3)6-5-7-13(4)10-15(14)16/h7-8H,5-6,9-10H2,1-4H3/b12-8+,13-7+
• InChIKey: CAULGCQHVOVVRN-SWZPTJTJSA-N
• PubChem CID: 6436348

Type(s) of Resistant Mechanism of This Drug

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-16: Genitourinary system diseases

Chronic kidney disease [ICD-11: GB61]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: hsa_circRNA_0000309 [1]

• Molecule Alteration: Expression; Down-regulation
• Resistant Disease: Diabetic nephropathy [ICD-11: GB61.Z]
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: MPC5 cells; Kidney; Mus musculus (Mouse); CVCL_AS87
• In Vivo Model: C57BL/6J mouse model; C57BL/KsJ mouse model; db/db mice mouse model; Mus musculus
• Experiment for Molecule Alteration: qRT-PCR
• Mechanism Description: Mmu_circRNA_0000309 silence mediates drug resistance to germacrone in DN mice. mmu_circRNA_0000309 sponges miR-188-3p, and subsequently upregulates GPX4 expression, inactivating ferroptosis-dependent mitochondrial function and podocyte apoptosis.

Key Molecule: hsa_circRNA_0000309 [1]

• Molecule Alteration: Expression; Down-regulation
• Resistant Disease: Diabetic nephropathy [ICD-11: GB61.Z]
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: MPC5 cells; Kidney; Mus musculus (Mouse); CVCL_AS87
• In Vivo Model: C57BL/6J mouse model; C57BL/KsJ mouse model; db/db mice mouse model; Mus musculus
• Experiment for Molecule Alteration: qRT-PCR
• Mechanism Description: Mmu_circRNA_0000309 silence mediates drug resistance to germacrone in DN mice. mmu_circRNA_0000309 sponges miR-188-3p, and subsequently upregulates GPX4 expression, inactivating ferroptosis-dependent mitochondrial function and podocyte apoptosis.

References

• Ref 1: A Novel Identified Circular RNA, mmu_mmu_circRNA_0000309, Involves in Germacrone-Mediated Improvement of Diabetic Nephropathy Through Regulating Ferroptosis by Targeting miR-188-3p/GPX4 Signaling Axis .Antioxid Redox Signal. 2022 Apr;36(10-12):740-759. doi: 10.1089/ars.2021.0063. 10.1089/ars.2021.0063