Molecule Information

General Information of the Molecule (ID: Mol02111)
Name
Phosphodiesterase III (PDE) ,Homo sapiens
Synonyms
PDE
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Molecule Type
Protein
Gene Name
PDE
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Cilostazol
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Disease Class: Coronary artery disease [1]
Sensitive Disease Coronary artery disease [ICD-11: BA8Z.0]
 Disease Info 
Sensitive Drug Cilostazol
 Drug Info 
Molecule Alteration Function
Inhibition
Experimental Note Identified from the Human Clinical Data
Cell Pathway Regulation JAK2 signaling pathway Activation hsa04917
STAT3 signaling pathway Activation hsa04550
Mechanism Description Cilostazol has been implicated in a number of other basic pathways including the inhibition of adenosine reuptake, the inhibition of multidrug resistance protein 4, among others. Mouse models of myocardial ischemia reperfusion have associated cilostazol with attenuation of multiple inflammatory markers through activation of PPAR gamma, JAK2, and STAT3 pathways
Disease Class: Coronary artery disease [1]
Sensitive Disease Coronary artery disease [ICD-11: BA8Z.0]
 Disease Info 
Sensitive Drug Cilostazol
 Drug Info 
Molecule Alteration Function
Inhibition
Experimental Note Identified from the Human Clinical Data
Cell Pathway Regulation JAK2 signaling pathway Activation hsa04917
STAT3 signaling pathway Activation hsa04550
Mechanism Description Cilostazol has been implicated in a number of other basic pathways including the inhibition of adenosine reuptake, the inhibition of multidrug resistance protein 4, among others. Mouse models of myocardial ischemia reperfusion have associated cilostazol with attenuation of multiple inflammatory markers through activation of PPAR gamma, JAK2, and STAT3 pathways
Disease Class: Cerebral artery disease [1]
Sensitive Disease Cerebral artery disease [ICD-11: 8B26.2]
 Disease Info 
Sensitive Drug Cilostazol
 Drug Info 
Molecule Alteration Function
Inhibition
Experimental Note Identified from the Human Clinical Data
Cell Pathway Regulation JAK2 signaling pathway Activation hsa04917
STAT3 signaling pathway Activation hsa04550
Mechanism Description Cilostazol has been implicated in a number of other basic pathways including the inhibition of adenosine reuptake, the inhibition of multidrug resistance protein 4, among others. Mouse models of myocardial ischemia reperfusion have associated cilostazol with attenuation of multiple inflammatory markers through activation of PPAR gamma, JAK2, and STAT3 pathways
Disease Class: Cerebral artery disease [1]
Sensitive Disease Cerebral artery disease [ICD-11: 8B26.2]
 Disease Info 
Sensitive Drug Cilostazol
 Drug Info 
Molecule Alteration Function
Inhibition
Experimental Note Identified from the Human Clinical Data
Cell Pathway Regulation JAK2 signaling pathway Activation hsa04917
STAT3 signaling pathway Activation hsa04550
Mechanism Description Cilostazol has been implicated in a number of other basic pathways including the inhibition of adenosine reuptake, the inhibition of multidrug resistance protein 4, among others. Mouse models of myocardial ischemia reperfusion have associated cilostazol with attenuation of multiple inflammatory markers through activation of PPAR gamma, JAK2, and STAT3 pathways
Disease Class: Carotid artery disease [1]
Sensitive Disease Carotid artery disease [ICD-11: 8B10.Y]
 Disease Info 
Sensitive Drug Cilostazol
 Drug Info 
Molecule Alteration Function
Inhibition
Experimental Note Identified from the Human Clinical Data
Cell Pathway Regulation JAK2 signaling pathway Activation hsa04917
STAT3 signaling pathway Activation hsa04550
Mechanism Description Cilostazol has been implicated in a number of other basic pathways including the inhibition of adenosine reuptake, the inhibition of multidrug resistance protein 4, among others. Mouse models of myocardial ischemia reperfusion have associated cilostazol with attenuation of multiple inflammatory markers through activation of PPAR gamma, JAK2, and STAT3 pathways
Disease Class: Carotid artery disease [1]
Sensitive Disease Carotid artery disease [ICD-11: 8B10.Y]
 Disease Info 
Sensitive Drug Cilostazol
 Drug Info 
Molecule Alteration Function
Inhibition
Experimental Note Identified from the Human Clinical Data
Cell Pathway Regulation JAK2 signaling pathway Activation hsa04917
STAT3 signaling pathway Activation hsa04550
Mechanism Description Cilostazol has been implicated in a number of other basic pathways including the inhibition of adenosine reuptake, the inhibition of multidrug resistance protein 4, among others. Mouse models of myocardial ischemia reperfusion have associated cilostazol with attenuation of multiple inflammatory markers through activation of PPAR gamma, JAK2, and STAT3 pathways
References
Ref 1 Cilostazol: a Review of Basic Mechanisms and Clinical Uses .Cardiovasc Drugs Ther. 2021 Apr 16. doi: 10.1007/s10557-021-07187-x. Online ahead of print. 10.1007/s10557-021-07187-x

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