Molecule Information

General Information of the Molecule (ID: Mol02047)

Name	Thioredoxin (TRX) ,Clostridioides difficile
Synonyms	cotE; CD630_14330 Click to Show/Hide
Molecule Type	Protein
Gene Name	TRX
Sequence	MIYMPNLPSLGSKAPDFKANTTNGPIRLSDYKGNWIVLFSHPGDFTPVCTTEFLCFAKYY DEFKKRNTELIGLSVDSNSSHLAWMYNISLLTGVEIPFPIIEDRDMRIAKLYGMISKPMS DTSTVRSVFIIDNNQILRTILYYPLTTGRNIPEILRIVDALQTSDRDNIVTPANWFPGMP VILPYPKNYKELKNRVNSCNKKYSCMDWYLCFVPDNYNDEEVSKKIDNTCSWKKEHTKNI ENECNCEHEHHDYLNKALDCKQEHKTDIKDDCNHEKKHTKNTNKVHNSKQDKFKDKSCDE MNFNYDKDESCDKINSSYNKEDSSYEDFYKHNYKNYDYTSEKNTKKIAMKTLKDSKKLVR PQITDPYNPIVENANCPDINPIVAEYVLGNPTNVDAQLLDAVIFAFAEIDQSGNLFIPYP RFLNQLLALKGEKPSLKVIVAIGGWGAEGFSDAALTPTSRYNFARQVNQMINEYALDGID IDWEYPGSSASGITSRPQDRENFTLLLTAIRDVIGDDKWLSVAGTGDRGYINSSAEIDKI APIIDYFNLMSYDFTAGETGPNGRKHQANLFDSDLSLPGYSVDAMVRNLENAGMPSEKIL LGIPFYGRLGATITRTYDELRRDYINKNGYEYRFDNTAQVPYLVKDGDFAMSYDDALSIF LKTQYVLRNCLGGVFSWTSTYDQANILARTMSIGINDPEVLKEELEGIYGQF Click to Show/Hide
Function	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Click to Show/Hide
Uniprot ID	Q18BV5_CLOD6
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Firmicutes Class: Clostridia Order: Eubacteriales Family: Peptostreptococcaceae Genus: Clostridioides Species: Clostridioides difficile

Type(s) of Resistant Mechanism of This Molecule

DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

Click to Show/Hide the Full List of Drugs

Metronidazole

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Drug Inactivation by Structure Modification (DISM)		Click to Show/Hide
Disease Class: Clostridium difficile infection			[1]
Resistant Disease	Clostridium difficile infection [ICD-11: 1A04.0]		Disease Info
Resistant Drug	Metronidazole		Drug Info
Molecule Alteration	Expression	Down-regulation
Experimental Note	Discovered Using In-vivo Testing Model
Mechanism Description	The decrement of redox proteins including pyruvate:ferredoxin oxidoreductase (OR), pyruvate:flavodoxin OR, thioredoxin and thioredoxin reductase are thought to be responsible for MTZ resistance as they are required for drug activation.
Disease Class: Clostridium difficile infection			[1]
Resistant Disease	Clostridium difficile infection [ICD-11: 1A04.0]		Disease Info
Resistant Drug	Metronidazole		Drug Info
Molecule Alteration	Expression	Down-regulation
Experimental Note	Discovered Using In-vivo Testing Model
Mechanism Description	The decrement of redox proteins including pyruvate:ferredoxin oxidoreductase (OR), pyruvate:flavodoxin OR, thioredoxin and thioredoxin reductase are thought to be responsible for MTZ resistance as they are required for drug activation.

References

Ref 1	Insights into drug resistance mechanisms in Clostridium difficile .Essays Biochem. 2017 Mar 3;61(1):81-88. doi: 10.1042/EBC20160062. Print 2017 Feb 28. 10.1042/EBC20160062