Molecule Information

General Information of the Molecule (ID: Mol02004)

Name	UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MURA) ,Escherichia coli
Synonyms	murA; murZ; b3189; JW3156 Click to Show/Hide
Molecule Type	Protein
Gene Name	MURA
Gene ID	947703
Sequence	MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQL GAKVERNGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARFGQGQVSLPGGCTIGAR PVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAHIVMDKVSVGATVTIMCAATLAEGTT IIENAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGGGVYRVLPDRIETGTFLV AAAISRGKIICRNAQPDTLDAVLAKLRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHP AFPTDMQAQFTLLNLVAEGTGFITETVFENRFMHVPELSRMGAHAEIESNTVICHGVEKL SGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYERIEDKLRALGANIERVKGE Click to Show/Hide
Function	Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Target for the antibiotic fosfomycin. Click to Show/Hide
Uniprot ID	MURA_ECOLI
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Kingdom: N.A. Phylum: Proteobacteria Class: Gammaproteobacteria Order: 91347 Family: Enterobacteriaceae Genus: Escherichia Species: Escherichia coli

Type(s) of Resistant Mechanism of This Molecule

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Fosfomycin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)			Click to Show/Hide
Disease Class: Escherichia coli infection				[1]
Resistant Disease	Escherichia coli infection [ICD-11: 1A03.0]			Disease Info
Resistant Drug	Fosfomycin			Drug Info
Molecule Alteration	Expression		Inherence
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	THP1 cells	Pleural effusion	Homo sapiens (Human)	CVCL_0006
Mechanism Description	Overexpression of the murA gene by induction of a regulated promoter can lead to greatly increased MICs, to levels that would afford clinical resistance, while having relatively low effects on fitness (relative to mutations to fosfomycin resistance found in clinical isolates).

References

Ref 1	Fosfomycin: Mechanism and Resistance .Cold Spring Harb Perspect Med. 2017 Feb 1;7(2):a025262. doi: 10.1101/cshperspect.a025262. 10.1101/cshperspect.a025262