Molecule Information

General Information of the Molecule (ID: Mol01325)

• Name: E2F1-regulated inhibitor of cell death (ERICD) ,Homo sapiens
• Synonyms: ERICD
• Molecule Type: LncRNA
• Gene Name: LINC00586
• Gene ID: 104355217
• Location: chr8:140636281-140638283[+]
• Ensembl ID: ENSG00000280303
• HGNC ID: HGNC:49404

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Etoposide

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Disease Class: Osteosarcoma [1]

• Sensitive Disease: Osteosarcoma [ICD-11: 2B51.0]
• Sensitive Drug: Etoposide
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: SAOS-2 cells; Bone marrow; Homo sapiens (Human); CVCL_0548
• In Vitro Model: U2OS cells; Bone; Homo sapiens (Human); CVCL_0042
• Experiment for Molecule Alteration: RT-PCR
• Experiment for Drug Resistance: Fluorescence-activated cell sorting analysis
• Mechanism Description: The long non-coding RNA ERIC is regulated by E2F and modulates the cellular response to DNA damage, ERIC levels were increased following DNA damage by the chemotherapeutic drug Etoposide, and inhibition of ERIC expression enhanced Etoposide -induced apoptosis.

References

• Ref 1: The long non-coding RNA ERIC is regulated by E2F and modulates the cellular response to DNA damage. Mol Cancer. 2013 Oct 29;12(1):131. doi: 10.1186/1476-4598-12-131.