General Information of the Molecule (ID: Mol01232)
Name
Long non-protein coding RNA 1118 (LINC01118) ,Homo sapiens
Synonyms
LINC01118
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Molecule Type
LncRNA
Gene Name
GTL2, LINC00023, NCRNA00023, onco-lncRNA-83
Gene ID
388948
Location
chr2:46698940-46822804[+]
Ensembl ID
ENSG00000222005
HGNC ID
HGNC:49261
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Paclitaxel
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Disease Class: Epithelial ovarian cancer [1]
Resistant Disease Epithelial ovarian cancer [ICD-11: 2B5D.0]
Resistant Drug Paclitaxel
Molecule Alteration Expression
Up-regulation
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Inhibition hsa04210
Cell invasion Activation hsa05200
Cell migration Activation hsa04670
In Vitro Model SkOV3 cells Ovary Homo sapiens (Human) CVCL_0532
A2780 cells Ovary Homo sapiens (Human) CVCL_0134
COC1 cells Ovary Homo sapiens (Human) CVCL_6891
SkOV3-TR30 cells Ovary Homo sapiens (Human) CVCL_0532
Experiment for
Molecule Alteration
qPCR
Experiment for
Drug Resistance
MTS assay; Flow cytometry assay
Mechanism Description LINC01118 Can enhance ABCC1 expression by suppressing miR-134 expression to promote paclitaxel resistance in epithelial ovarian cancer.
References
Ref 1 LINC01118 Modulates Paclitaxel Resistance of Epithelial Ovarian Cancer by Regulating miR-134/ABCC1. Med Sci Monit. 2018 Dec 6;24:8831-8839. doi: 10.12659/MSM.910932.

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