Molecule Information

General Information of the Molecule (ID: Mol01200)

• Name: acrB-acrA (Unclear) ,Homo sapiens
• Molecule Type: Protein
• Gene Name: acrB-acrA

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Tetracycline

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Disease Class: Bacterial infection [1]

• Resistant Disease: Bacterial infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Tetracycline
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Experiment for Molecule Alteration: High-throughput sequencing assay
• Mechanism Description: Relative abundance of ARGs was significantly increased under high oxytetracycline concentration. Of the 36 ARG-carrying contigs in the OTC-25 plasmidome, 20 were matched in the NCBI Plasmid Genome Database, with 17 carrying multiple ARGs (carrying >= 2 ARGs), including gene combinations of pecM-tetA-tetR-qnrS1, tet31-tetR(31) (tetR(31), which is used to regulate the expression of tet31 gene, is one kind of tetR (tetracycline repressor gene)), floR-sul1, strA-strB, acrB-acrA, ATP-binding cassette transporter (ABC transporter)-ABC transporter, and mexC.

References

• Ref 1: Characteristics of ARG-carrying plasmidome in the cultivable microbial community from wastewater treatment system under high oxytetracycline concentration. Appl Microbiol Biotechnol. 2018 Feb;102(4):1847-1858. doi: 10.1007/s00253-018-8738-6. Epub 2018 Jan 13.