Molecule Information

General Information of the Molecule (ID: Mol01170)

• Name: Major facilitator superfamily (MFS) ,Vibrio cholerae
• Molecule Type: Protein
• Gene Name: MFS

Kingdom: N.A.
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: Vibrio cholerae

Type(s) of Resistant Mechanism of This Molecule

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Tetracycline

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Disease Class: Vibrio cholerae infection [1]

• Sensitive Disease: Vibrio cholerae infection [ICD-11: 1A00.0]
• Sensitive Drug: Tetracycline
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: E1 Tor C6706; 1124478
• In Vivo Model: Infant mouse colonisation; Mus musculus
• Experiment for Molecule Alteration: Lux reporters assay
• Experiment for Drug Resistance: Plate counting assay
• Mechanism Description: Deletion of all five mfs genes results in increased susceptibility to tetracycline and the antimicrobial agents present in crud.

References

• Ref 1: LysR family activator-regulated major facilitator superfamily transporters are involved in Vibrio cholerae antimicrobial compound resistance and intestinal colonisation. Int J Antimicrob Agents. 2013 Feb;41(2):188-92. doi: 10.1016/j.ijantimicag.2012.10.008. Epub 2012 Nov 30.