Molecule Information

General Information of the Molecule (ID: Mol01160)

• Name: rgt1438 (Unclear) ,Streptomyces speibonae
• Molecule Type: Protein
• Gene Name: rgt1438
• Sequence:
  MRMLLTTYGSRGDVEPLAGLAAGLRKLGVEARVCAPPDEEFAALPARAGVPLIPLGPPVR
  PVVAGERPPTPQDAFRLAAELVTARFDTLTEAAEGCQAVLATGLMPAGVRDVAEKLGIPY
  VFACFHIYGLPSRHFPPGARPGTPPAPDGTDHRELWEQDARSVNALYGDALNRHRTGIGL
  PPVRNVRDHVLTDRPWLAADPVLCPAEGMTEFDLVQTGPWFLPDERPLPAGLEEFLGAGA
  PPVYVGFGSMGAYAPEGIARVAVEACRAQGRRVVLARGWAGLTPDDGGADCFAVGEVNQQ
  ALFRRVAAVVHHGGAGTTTTAARAGAPQVVVPRIADQPYWAERVRDLGIGSAHPDPVVTF
  DSLSAALTTALAPEVRARARTVAGTIRTDGASVAARLLVETADRAGRPVSP

Kingdom: N.A.
Phylum: Actinobacteria
Class: Actinomycetia
Order: Streptomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: Streptomyces speibonae

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Rifampin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Bacterial infection [1]

• Resistant Disease: Bacterial infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Rifampin
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Streptomyces albus J1074; 457425
• In Vitro Model: Streptomyces speibonae WAC1438; 195801
• Experiment for Molecule Alteration: Whole genome sequence assay; Allelic frequency measurement assay
• Experiment for Drug Resistance: MIC assay
• Mechanism Description: Rgt1438R encode a rifampin-inactivating glycosyltransferase,as a rifampin resistance determinant from WAC1438 capable of inactivating an assortment of rifamycins.

References

• Ref 1: Characterization of a rifampin-inactivating glycosyltransferase from a screen of environmental actinomycetes. Antimicrob Agents Chemother. 2012 Oct;56(10):5061-9. doi: 10.1128/AAC.01166-12. Epub 2012 Jul 16.