Molecule Information

General Information of the Molecule (ID: Mol01152)

• Name: Chloramphenicol resistance protein (Tn5561-Unclear) ,Rhodococcus erythropolis
• Molecule Type: Protein
• Gene Name: Tn5561

Kingdom: N.A.
Phylum: Actinobacteria
Class: Actinomycetia
Order: Corynebacteriales
Family: Nocardiaceae
Genus: Rhodococcus
Species: Rhodococcus erythropolis

Type(s) of Resistant Mechanism of This Molecule

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Chloramphenicol

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Disease Class: Rhodococcus erythropolis infection [1]

• Resistant Disease: Rhodococcus erythropolis infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Chloramphenicol
• Molecule Alteration: Expression; Inherence
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Rhodococcus erythropolis strain SQ1; 1833
• Experiment for Molecule Alteration: Southern hybridization assay
• Mechanism Description: Three copies of the IS21-related transposable element IS1415 were identified in Rhodococcus erythropolis NI86/21. Adjacent to one of the IS1415 copies, a 47-bp sequence nearly identical to the conserved 5* end of integrons was found. Accurate transposition of IS1415 carrying a chloramphenicol resistance gene (Tn5561) was demonstrated following delivery from a suicide vector to R. erythropolis SQ1.

References

• Ref 1: Transposition of the IS21-related element IS1415 in Rhodococcus erythropolis. J Bacteriol. 1997 Jul;179(14):4635-8. doi: 10.1128/jb.179.14.4635-4638.1997.