Molecule Information

General Information of the Molecule (ID: Mol01129)

Name	Uncharacterized MFS-type transporter EfpA (EFPA) ,Mycobacteriumtuberculosis
Synonyms	Efflux protein A; Rv2846c Click to Show/Hide
Molecule Type	Protein
Gene Name	efpA
Gene ID	888575
Sequence	MTALNDTERAVRNWTAGRPHRPAPMRPPRSEETASERPSRYYPTWLPSRSFIAAVIAIGG MQLLATMDSTVAIVALPKIQNELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRT FIVGVALFTISSVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPARNAAT AVFAAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRETNKERMKLDA TGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAAVAFVIVERTAENPVVPFHL FRDRNRLVTFSAILLAGGVMFSLTVCIGLYVQDILGYSALRAGVGFIPFVIAMGIGLGVS SQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHRGVPYFPNLVMPIVVGGIGIGMAVVPLT LSAIAGVGFDQIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQL AALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAGEL Click to Show/Hide
Uniprot ID	EFPA_MYCTU
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Actinobacteria Class: Actinomycetia Order: Corynebacteriales Family: Mycobacteriaceae Genus: Mycobacterium Species: Mycobacterium tuberculosis

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Rifampin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: HIV-infected patients with tuberculosis			[1], [2], [3]
Resistant Disease	HIV-infected patients with tuberculosis [ICD-11: 1C60.0]		Disease Info
Resistant Drug	Rifampin		Drug Info
Molecule Alteration	Expression	Up-regulation
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Mycobacterium tuberculosis H37Rv		83332
	Mycobacterium tuberculosis MTB1		1773
	Mycobacterium tuberculosis MTB2		1773
Experiment for Molecule Alteration	Whole genome sequence assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	The induced strains presented an increased efflux activity that was inhibited by the efflux inhibitors (EIs) and showed overexpression of the efflux pump genes efpA, mmpL7, mmr, p55 and the Tap-like gene Rv1258c. Altogether, these results correlate efflux activity with INH resistance and demonstrate that efflux pumps play an important role in acquired INH resistance in M. tuberculosis complex.

References

Ref 1	Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis. Antimicrob Agents Chemother. 2004 Jul;48(7):2415-23. doi: 10.1128/AAC.48.7.2415-2423.2004.
Ref 2	Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex. Infect Genet Evol. 2012 Jun;12(4):695-700. doi: 10.1016/j.meegid.2011.08.009. Epub 2011 Aug 17.
Ref 3	Mycobacterium tuberculosis efpA encodes an efflux protein of the QacA transporter family. Clin Diagn Lab Immunol. 1997 Jan;4(1):23-32. doi: 10.1128/cdli.4.1.23-32.1997.