Molecule Information

General Information of the Molecule (ID: Mol01127)

Name	Type IV pilus biogenesis and competence protein PilQ (PILQ) ,Neisseria gonorrhoeae
Synonyms	Outer membrane protein Omc; omc Click to Show/Hide
Molecule Type	Protein
Gene Name	pilQ
Sequence	MNTKLTKIISGLFVATAAFQTASAGNITDIKVSSLPNKQKIVKVSFDKEIVNPTGFVTSS PARIALDFEQTGISMDQQVLEYADPLLSKISAAQNSSRARLVLNLNKPGQYNTEVRGNKV WIFINESDDTVSAPARPAVKAAPAAPAKQQAAAPFTESVVSVSAPFSPAKQQAAASAKQQ AATPAKQTNIDFRKDGKNAGIIELAALGFAGQPDISQQHDHIIVTLKNHTLPTALQRSLD VADFKTPVQKVTLKRLNNDTQLIITTTGNWELVNKSAAPGYFTFQVLPKKQNLESGGVNN APKTFTGRKISLDFQDVEIRTILQILAKESGMNIVASDSVSGKMTLSLKDVPWDQALDLV MQARNLDMRQQGNIVNMAPRRAACQRQSLLTSGKRHCRSGRAVFPKLPIEIQKCGRIPQH PALDNADTTGNRNTLVSGRGSVLIDPATNTLIVTDTRSVIEKFRKLIDELDVPAQQVMIE ARIVEAADGFSRDLGVKFGATGRKKLKNETSAFGWGVNSGFGGGDKWEAKPKSTCRLPCR KQHFAGARDFSGALNLELSASESLSKTKTLANPRVLTQNRKEAKIESGYEIPFTVTTRSG GGNSTNTELKKAVLGLTVTANITPDGQIIMTVKINKDSPRQCASGNNTILCISTKSLNTQ AMVENGGTLIVGGIYEENNGNTLTKVPLLATSPLSATSLKHSGKNRPPRTADFQLPPREL Click to Show/Hide
Function	Required for type IV pilus biogenesis and competence. Could function as a pore for exit of the pilus but also as a channel for entry of heme and antimicrobial agents and uptake of transforming DNA. Click to Show/Hide
Uniprot ID	PILQ_NEIGO
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Proteobacteria Class: Betaproteobacteria Order: Neisseriales Family: Neisseriaceae Genus: Neisseria Species: Neisseria gonorrhoeae

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Ceftriaxone

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Gonococcal infection			[1]
Resistant Disease	Gonococcal infection [ICD-11: 1A70.0]		Disease Info
Resistant Drug	Ceftriaxone		Drug Info
Molecule Alteration	Missense mutation	p.G666K
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Neisseria gonorrhoeae PR100		485
Experiment for Molecule Alteration	PCR amplification and DNA sequence assay
Experiment for Drug Resistance	MIC assay
Mechanism Description	Antibiotic resistance mediated by penC is the result of a Glu-666 to Lys missense mutation in the pilQ gene that interferes with the formation of the SDS-resistant high-molecular-mass PilQ secretin complex, disrupts piliation, and decreases transformation frequency by 50-fold.

References

Ref 1	The penC mutation conferring antibiotic resistance in Neisseria gonorrhoeae arises from a mutation in the PilQ secretin that interferes with multimer stability. Mol Microbiol. 2005 Sep;57(5):1238-51. doi: 10.1111/j.1365-2958.2005.04752.x.