Molecule Information

General Information of the Molecule (ID: Mol01121)

• Name: TMB-2 metallo-beta-lactamase (BTMB2) ,Acinetobacter pittii
• Synonyms: blaTMB-2; TMB-2 metallo-beta-lactamase
• Molecule Type: Protein
• Gene Name: blaTMB-2
• Sequence:
  MRPFLFLIIFISHFAFANEEIPGLEVEEIDNGVFLHKSYSRVEGWGLVSSNGLVVISGGK
  AFIIDTPWSESDTEKLVDWIRSKKYELAGSISTHSHEDKTAGIKWLNGKSITTYASALTN
  EILKREGKEQARSSFKGNEFSLMDGFLEVYYPGGGHTIDNLVVWIPSSKILYGGCFIRSL
  EPSGLGYTGEAKIDQWPQSARNTISKYPEAKIVVPGHGKIGDFELLKHTKVLAEKASNKA
  NHGDR
• Uniprot ID: L0N611_ACIPI

Kingdom: N.A.
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Moraxellales
Family: Moraxellaceae
Genus: Acinetobacter
Species: Acinetobacter pittii

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Ceftazidime

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Bacterial infection [1]

• Resistant Disease: Bacterial infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Ceftazidime
• Molecule Alteration: Expression; Inherence
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Acinetobacter genomospecies 14BJ MRY12-226; 48296
• In Vitro Model: Acinetobacter pittii. MRY12-142; 1255681
• Experiment for Drug Resistance: Etest assay
• Mechanism Description: Tripoli metallo-Beta-lactamase 2 (TMB-2), a variant of blaTMB-1 can inactivate the Beta-lactams.

References

• Ref 1: Detection of tripoli metallo-Beta-lactamase 2 (TMB-2), a variant of blaTMB-1, in clinical isolates of Acinetobacter spp. in Japan. J Antimicrob Chemother. 2013 Jun;68(6):1441-2. doi: 10.1093/jac/dkt031. Epub 2013 Feb 6.