General Information of the Molecule (ID: Mol01119)
Name
Tetracycline resistance protein TetW (TETW) ,Selenomonas ruminantium
Synonyms
tet(W); TetW
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Molecule Type
Protein
Gene Name
tet(W)
Sequence
MKIINIGILAHVDAGKTTLTESLLYASGAISEPGSVEKGTTRTDTMFLERQRGITIQAAV
TSFQWHRCKVNIVDTPGHMDFLAEVYRSLAVLDGAILVISAKDGVQAQTRILFHALRKMN
IPTVIFINKIDQAGVDLQSVVQSVRDKLSADIIIKQTVSLSPEIVLEENTDIEAWDAVIE
NNDKLLEKYIAGEPISREKLVREEQRRVQDASLFPVYYGSAKKGLGIQPLMDAVTGLFQP
IGEQGSAALCGSVFKVEYTDCGQRRVYLRLYSGTLRLRDTVALAGREKLKITEMRIPSKG
EIVRTDTAYPGEIVILPSDSVRLNDVLGDPTRLPRKRWREDPLPMLRTSIAPKTAAQRER
LLDALTQLADTDPLLRCEVDSITHEIILSFLGRVQLEVVSALLSEKYKLETVVKEPTVIY
MERPLKAASHTIHIEVPPNPFWASIGLSVTPLSLGSGVQYESRVSLGYLNQSFQNAVRDG
IRYGLEQGLFGWNVTDCKICFEYGLYYSPVSTPADFRSLAPIVLEQALKESGTQLLEPYL
SFTLYAPREYLSRAYHDAPKYCATIETVQVKKDEVVFTGEIPARCIQAYRTDLAFYTNGQ
SVCLTELKGYQAAVGKPVIQPRRPNSRLDKVRHMFQKVM
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Function
Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes.
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Uniprot ID
Q2PYV5_SELRU
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Kingdom: N.A.
Phylum: Firmicutes
Class: Negativicutes
Order: Selenomonadales
Family: Selenomonadaceae
Genus: Selenomonas
Species: Selenomonas ruminantium
Type(s) of Resistant Mechanism of This Molecule
  ADTT: Aberration of the Drug's Therapeutic Target
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Tetracycline
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Disease Class: Selenomonas ruminantium infection [1]
Resistant Disease Selenomonas ruminantium infection [ICD-11: 1A00-1C4Z]
Resistant Drug Tetracycline
Molecule Alteration Expression
Inherence
Experimental Note Identified from the Human Clinical Data
In Vitro Model Bifidobacterium longum strain F10 216816
Bifidobacterium longum strain F5 216816
Bifidobacterium longum strain F8 216816
Butyrivibrio fibrisolvens strain 1.23 831
Butyrivibrio fibrisolvens strain 1.230 831
Butyrivibrio fibrisolvens strain Jk214 831
Butyrivibrio fibrisolvens strain Jk51 831
Fusobacterium prausnitzii strain k10 853
Mitsuokella multiacidus strain 46/5(2) 52226
Mitsuokella multiacidus strain P208-58 52226
Selenomonas ruminantium strain FB32 971
Selenomonas ruminantium strain FB322 971
Selenomonas ruminantium strain FB34 971
Experiment for
Molecule Alteration
Southern blotting assay
Mechanism Description Members of our group recently identified a new tetracycline resistance gene, tet(W), in three genera of rumen obligate anaerobes. Here, we show that tet(W) is also present in bacteria isolated from human feces. The tet(W) genes found in human Fusobacterium prausnitzii and Bifidobacterium longum isolates were more than 99.9% identical to those from a rumen isolate of Butyrivibrio fibrisolvens.
References
Ref 1 Occurrence of the new tetracycline resistance gene tet(W) in bacteria from the human gut. Antimicrob Agents Chemother. 2000 Mar;44(3):775-7. doi: 10.1128/AAC.44.3.775-777.2000.

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