Molecule Information

General Information of the Molecule (ID: Mol01115)

• Name: Tetracycline resistance protein TetQ (TETQ) ,Bacteroides uniformis
• Synonyms: tetM; DW831_19585; DW873_18575; DWW14_02360; DWW83_14920; DWX87_03315; DXB37_20400; DXC07_01500; DXC80_18025; DXD40_14425; ERS852510_00445; ERS852554_00456; GAP41_13825; GAP47_05320; GAP55_14175; GAQ44_06250; GAQ59_16410; GAQ70_12255; GAQ75_13645; HMPREF2141_02710; HUU98_20000; HUV07_17965
• Molecule Type: Protein
• Gene Name: tet(Q)
• Gene ID: 64352988
• Sequence:
  MNIINLGILAHIDAGKTSVTENLLFASGATEKCGRVDNGDTITDSMDIEKRRGITVRAST
  TSIIWNGVKCNIIDTPGHMDFIAEVERTFKMLDGAVLILSAKEGIQAQTKLLFSTLQKLQ
  IPTIIFINKIDRAGVNLERLYMDIKTNLSQDVLFMQTVVDGSVYPVCSQTYIKEEYKEFV
  CNHDDDILERYLADSEISPADYWNTIIALVAKAKVYPVLHGSAMFNIGINELLDAISSFI
  LPPASVSNRLSAYLYKIEHDPKGHKRSFLKIIDGSLRLRDVVRINDSEKFIKIKNLKTIY
  QGREINVDEVGANDIAIVEDIEDFRIGDYLGAKPCLIQGLSHQHPALKSSVRPNKPEERS
  KVISALNTLWIEDPSLSFSINSYSDELEISLYGLTQKEIIQTLLEERFSVKVHFDEIKTI
  YKERPIKKVNKIIQIEVPPNPYWATIGLTLEPLPLGAGLQIESDISYGYLNHSFQNAVFE
  GIRMSCQSGLHGWEVTDLKVTFTQAEYYSPVSTPADFRQLTPYVFRLALQQSGVDILEPM
  LCFELQIPQVASSKAITDLQKLMSEIEDISCNNEWCHIKGKVPLNTSKDYASEVSSYTKG
  LGIFMVKPCGYQITKDGYSDNIRMNEKDKLLFMFQKSMSLK
• Function: Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes.
• Uniprot ID: A0A139K3N9_BACUN

Kingdom: N.A.
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides uniformis

Type(s) of Resistant Mechanism of This Molecule

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Tetracycline

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Disease Class: Bacteroides uniformis infection [1]

• Resistant Disease: Bacteroides uniformis infection [ICD-11: 1C4Y.11]
• Resistant Drug: Tetracycline
• Molecule Alteration: Expression; Inherence
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Bacteroides distasonis strains; 823
• In Vitro Model: Bacteroides distasonis strains V2002; 823
• In Vitro Model: Bacteroides distasonis strains V2003; 823
• In Vitro Model: Bacteroides distasonis strains V2004; 823
• In Vitro Model: Bacteroides fragilis strain; 817
• In Vitro Model: Bacteroides fragilis strain V503; 817
• In Vitro Model: Bacteroides ovatus strains; 28116
• In Vitro Model: Bacteroides ovatus strains V2008; 28116
• In Vitro Model: Bacteroides thetaiotaomicron strain; 818
• In Vitro Model: Bacteroides thetaiotaomicron strain V2005; 818
• In Vitro Model: Bacteroides thetaiotaomicron strain V2006; 818
• In Vitro Model: Bacteroides thetaiotaomicron strain V2007; 818
• In Vitro Model: Bacteroides uniformis strain; 820
• In Vitro Model: Bacteroides uniformis strain V1760; 820
• In Vitro Model: Bacteroides uniformis strain V1761; 820
• In Vitro Model: Bacteroides uniformis strain V1918; 820
• In Vitro Model: Bacteroides uniformis strain V1921; 820
• In Vitro Model: Bacteroides uniformis strain V2000; 820
• In Vitro Model: Bacteroides uniformis strain V2001; 820
• In Vitro Model: Bacteroides uniformis strain V528; 820
• In Vitro Model: Bacteroides uniformis strain V844; 820
• Experiment for Molecule Alteration: Southern blotting assay
• Mechanism Description: Of 13 clinical isolates of the Bacteroides group, all were resistant to tetracycline (>10,ug/ml). The source of tetracycline resistance was investigated with the recently cloned tetQ gene, a ribosomal protection gene.

References

• Ref 1: Molecular survey of clindamycin and tetracycline resistance determinants in Bacteroides species. Antimicrob Agents Chemother. 1991 Nov;35(11):2415-8. doi: 10.1128/AAC.35.11.2415.