Molecule Information

General Information of the Molecule (ID: Mol01110)

Name	Tetracycline resistance protein TetM (TETM) ,Enterococcus faecalis
Synonyms	TetM(1545); tet(M) Click to Show/Hide
Molecule Type	Protein
Gene Name	tetM
Sequence	MKIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDRGTTKTDNTLLERQRGITIQTAI TSFQWKNTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKIG IPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVELHPNMRVMNFTESEQWDMVIE GNDYLLEKYTSGKLLEALELEQEESIRFHNCSLFPVYHGSAKNNIGIDNLIEVITNKFYS STHRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRDPVRISEKEKIKITEMYTSING ELCKIDKAYSGEIVILQNEFLKLNSVLGDTKLLPQRERIENPLPLLQTTVEPSKPQQREM LLDALLEISDSDPLLRYYVDSATHEIILSFLGKVQMEVTCALLQEKYHVEIEIKEPTVIY MERPLKKAEYTIHIEVPPNPFWASIGLSVAPLPLGSGVQYESSVSLGYLNQSFQNAVMEG IRYGCEQGLYGWNVTDCKICFKYGLYYSPVSTPADFRMLAPIVLEQVLKKAGTELLEPYL SFKIYAPQEYLSRAYNDAPKYCANIVDTQLKNNEVILSGEIPARCIQEYRSDLTFFTNGR SVCLTELKGYHVTTGEPVCQPRRPNSRIDKVRYMFNKIT Click to Show/Hide
Function	Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes. Click to Show/Hide
Uniprot ID	TET5_ENTFL
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Enterococcaceae Genus: Enterococcus Species: Enterococcus faecalis

Type(s) of Resistant Mechanism of This Molecule

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Tetracycline

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)		Click to Show/Hide
Disease Class: Enterococci infection			[1]
Resistant Disease	Enterococci infection [ICD-11: 1A00-1C4Z]		Disease Info
Resistant Drug	Tetracycline		Drug Info
Molecule Alteration	Expression	Acquired
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Enterococcus faecalis OG1RF:pCF10		474186
	Enterococcus faecalis OG1SSp		1351
In Vivo Model	House fly model		House fly
Experiment for Molecule Alteration	Bacterial colonies count assay
Experiment for Drug Resistance	Broth dilution assay
Mechanism Description	Tetracycline resistance of Musca domestica occurred by transferring the plasmid transduced with tetracycline resistance gene TETM of Enterococcus into Musca domestica.

References

Ref 1	Horizontal transfer of the tetracycline resistance gene tetM mediated by pCF10 among Enterococcus faecalis in the house fly (Musca domestica L.) alimentary canal. Microb Ecol. 2009 Oct;58(3):509-18. doi: 10.1007/s00248-009-9533-9. Epub 2009 May 28.