Molecule Information

General Information of the Molecule (ID: Mol01105)

Name	Tetracycline efflux proteintet(39) (TET39) ,Acinetobacterspp.(Acinetobacter baumannii)
Synonyms	tet39; Tet39 Click to Show/Hide
Molecule Type	Protein
Gene Name	tet39
Sequence	MPILPELLRSLAGAEAGGVHYGALLAVYALMQFIFAPILGALSDRFGRRPVLIISIAGAT ADYLLMAAAPSLLWLYIGRIFAGITGANMAVATAYVSDITPAHERAKRFGLLGAVFGIGF IAGPVIGGVLGEWNLHAPFFAAAFMNGINLIMTAVLLKESKHSNKMTEKVQEQSILKKLS YLITQPNMAPLLGIFLIITLVSQVPATLWVIYGQDRYGWSIFIAGVSLASYGICHSIAQA FAIAPMVKRFGEKNTLLCGIACDAIGLLLLSIAVEEWVPFALLPLFALGGVAVPALQAMM SRGISDERQGELQGLLSSFNSLGAIIGPVLVTSLYFMTQASAPGMVWALAAILYVITLPL LLKYRLNKYSGVP Click to Show/Hide
Function	Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter. Click to Show/Hide
Uniprot ID	A0A0M4FLY1_ACIBA
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Proteobacteria Class: Gammaproteobacteria Order: Moraxellales Family: Moraxellaceae Genus: Acinetobacter Species: Acinetobacter baumannii

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

Click to Show/Hide the Full List of Drugs

Tetracycline

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Acinetobacter baumannii infection			[1]
Resistant Disease	Acinetobacter baumannii infection [ICD-11: CA40.4]		Disease Info
Resistant Drug	Tetracycline		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Acinetobacter sp. LUH5605		309867
Experiment for Molecule Alteration	DNA multiple alignment assay
Experiment for Drug Resistance	Agar dilution method assay
Mechanism Description	Tet39 produces drug resistance through the action of nonspecific efflux pump.

References

Ref 1	Identification of Tet 39, a novel class of tetracycline resistance determinant in Acinetobacter spp. of environmental and clinical origin. J Antimicrob Chemother. 2005 Apr;55(4):566-9. doi: 10.1093/jac/dki051. Epub 2005 Mar 10.