Molecule Information

General Information of the Molecule (ID: Mol01104)

Name	Tetracycline efflux protein TetA (TETA) ,Corynebacterium glutamicum
Synonyms	tetA(33); TetA protein Click to Show/Hide
Molecule Type	Protein
Gene Name	tetA(33)
Sequence	MSSLTSARGSLATVLITASLDAAGMGLVMPILPALLHEAGVTADAVPLNVGVLIALYAVM QFIFAPVLGTLSDRFGRRRVLLVSLAGATVDYLVLATTSALSVFYIARAVAGITGATNAV TATVIADITPPHQRAKRFGLLSACYGGGMIAGPAMGGLFGAISPHLPFLLAALLSASNLA LTFILLRETRPDSPARSASLAQHRGRPGLSAVPGITFLLIAFGLVQFIGQAPGATWVLFT EHRLDWSPVEVGISLSVFGIVQVLVQALLTGRIVEWIGEAKTVIIGCITDALGLVGLAIV TDAFSMAPILAALGIGGIGLPALQTLLSQRVDEQHQGRLQGVLASINSVTSIFGPVAFTT IFALTYINADGFLWLCAAALYVPCVILIMRGTAASPKFGSWASGDSM Click to Show/Hide
Uniprot ID	Q8VVJ1_CORGT
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Actinobacteria Class: Actinomycetia Order: Corynebacteriales Family: Corynebacteriaceae Genus: Corynebacterium Species: Corynebacterium glutamicum

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

Click to Show/Hide the Full List of Drugs

Tetracycline

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Corynebacterium glutamicum infection			[1]
Resistant Disease	Corynebacterium glutamicum infection [ICD-11: 1A00-1C4Z]		Disease Info
Resistant Drug	Tetracycline		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Corynebacterium glutamicum ATCC 13032		196627
Experiment for Molecule Alteration	DNA sequencing assay
Experiment for Drug Resistance	Macrodilution broth method assay
Mechanism Description	Tet33 causes tetracycline resistance by regulating tetracycline efflux.

References

Ref 1	The 27.8-kb R-plasmid pTET3 from Corynebacterium glutamicum encodes the aminoglycoside adenyltransferase gene cassette aadA9 and the regulated tetracycline efflux system Tet 33 flanked by active copies of the widespread insertion sequence IS6100. Plasmid. 2002 Sep;48(2):117-29. doi: 10.1016/s0147-619x(02)00120-8.