Molecule Information

General Information of the Molecule (ID: Mol01103)

Name	Tetracycline efflux protein tet(L) (TETL) ,Streptococcus faecalis
Synonyms	tetL; tet; tet(L); CUM81_09970; EU507_16770; EY666_08885; L); Tetracycline resistant protein Click to Show/Hide
Molecule Type	Protein
Gene Name	tetL
Gene ID	66465484
Sequence	MNTSYSQSNLRHNQILIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFML TFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAF PALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPMITII TVPFLMKLLKKEVRIKGHFDIKGIILMSVGIVFFMLFTTSYSISFLIVSVLSFLIFVKHI RKVTDPFVDPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIF PGTMSVIIFGYIGGILVDRRGPLYVLNIGVTFLSVSFLTASFLLETTSWFMTIIIVFVLG GLSFTKTVISTIVSSSLKQQEAGAGMSLLNFTSFLSEGTGIAIVGGLLSIPLLDQRLLPM EVDQSTYLYSNLLLLFSGIIVISWLVTLNVYKHSQRDF Click to Show/Hide
Uniprot ID	Q7B6N8_ENTFL
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Enterococcaceae Genus: Enterococcus Species: Enterococcus faecalis

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Tetracycline

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Bacterial infection			[1], [2]
Resistant Disease	Bacterial infection [ICD-11: 1A00-1C4Z]		Disease Info
Resistant Drug	Tetracycline		Drug Info
Molecule Alteration	Expression	Up-regulation
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli strain Sk1592		562
Experiment for Molecule Alteration	Whole genome sequence assay
Experiment for Drug Resistance	Gradient plate method assay
Mechanism Description	The class L determinant, on the other hand, does not prevent the inhibition of protein synthesis in S. faecalis but rather decreases tetracycline uptake.The class L (TetL) tetracycline resistance determinant from streptococci specified resistance and an energy-dependent decreased accumulation of tetracycline in both Streptococcus faecalis and Escherichia coli.

References

Ref 1	Update on acquired tetracycline resistance genes. FEMS Microbiol Lett. 2005 Apr 15;245(2):195-203. doi: 10.1016/j.femsle.2005.02.034.
Ref 2	Energy-dependent efflux mediated by class L (tetL) tetracycline resistance determinant from streptococci. Antimicrob Agents Chemother. 1987 Oct;31(10):1648-50. doi: 10.1128/AAC.31.10.1648.