Molecule Information

General Information of the Molecule (ID: Mol01102)

Name	Tetracycline efflux protein (TET41) ,Serratia marcescens
Synonyms	TET41 Click to Show/Hide
Molecule Type	Protein
Gene Name	TET41
Sequence	MKKPMLVILLTVLLDAVGIGLIMPILPALLRSLGGLDAGSLHYGALLAAYALMQFLFSPI LGALSDRFGRRPVLLISLAGAAADYLLMAFAPTLAWLYLGRLLAGITGANMAVATAYVTD ITPAGQRARRFGLVGAVFGVGFIVGPLLGGSLGEWHLHAPFLAASAMNAVNLAMAFFLLP ESRKPRARAAEKIRLNPFSSLRRLHGKPGLLPLAGIYLIMALVSQAPATLWILYGQDRFG WSMMVAGLSLAGYGACHALSQAFAIGPLVARLGERKALLIGLAADAMGLALLSIATRGWA PFALLPFFAAGGMALPALQALMAQKVDDDHQGELQGTLASMGSLIGVAGPLVATALYAAT RDVWPGLVWALAAALYLLVPLLLARSRERDAA Click to Show/Hide
Function	Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter. Click to Show/Hide
Uniprot ID	A0A7S6YKU5_SERMA
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Actinobacteria Class: Actinomycetia Order: Corynebacteriales Family: Nocardiaceae Genus: Nocardia Species: Nocardia otitidiscaviarum

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Tetracycline

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Serratia marcescens infection			[1]
Resistant Disease	Serratia marcescens infection [ICD-11: 1A00-1C4Z]		Disease Info
Resistant Drug	Tetracycline		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli JM109		562
Experiment for Molecule Alteration	DNA sequencing and protein and phylogenetic assay
Experiment for Drug Resistance	MIC assay
Mechanism Description	Tet 41 is a tetracycline-specific efflux pump, which lead to drug resistance.

References

Ref 1	Novel tetracycline resistance determinant isolated from an environmental strain of Serratia marcescens. Appl Environ Microbiol. 2007 Apr;73(7):2199-206. doi: 10.1128/AEM.02511-06. Epub 2007 Feb 16.