Molecule Information

General Information of the Molecule (ID: Mol01100)

Name	Tetracycline efflux MFS transporter Tet(38) (TET38) ,Staphylococcus aureus
Synonyms	tet38; tet(38); DQV20_03865; G6X35_03865; G6Y24_14280; HK402_00520; 38; Tetracycline resistant protein Tet38 Click to Show/Hide
Molecule Type	Protein
Gene Name	tet38
Sequence	MNVEYSKIKKAVPILLFLFVFSLVIDNSFKLISVAIADDLNISVTTVSWQATLAGLVIGI GAVVYASLSDAISIRTLFIYGVILIIIGSIIGYIFQHQFPLLLVGRIIQTAGLAAAETLY VIYVAKYLSKEDQKTYLGLSTSSYSLSLVIGTLSGGFISTYLHWTNMFLIALIVVFTLPF LFKLLPKENNTNKAHLDFVGLILVATIATTVMLFITNFNWLYMIGALIAIIVFALYIKNA QRPLVNKSFFQNKRYASFLFIVFVMYAIQLGYIFTFPFIMEQIYHLQLDTTSLLLVPGYI VAVIVGALSGKIGEYLNSKQAIITAIILIALSLILPAFAVGNHISIFVISMIFFAGSFAL MYAPLLNEAIKTIDLNMTGVAIGFYNLIINVAVSVGIAIAAALIDFKALNFPGNDALSSH FGIILIILGLMSIVGLVLFVILNRWTQSEK Click to Show/Hide
Uniprot ID	Q5PU79_STAAU
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Firmicutes Class: Bacilli Order: Bacillales Family: Staphylococcaceae Genus: Staphylococcus Species: Staphylococcus aureus

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Tetracycline

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Staphylococcus aureus infection			[1]
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]		Disease Info
Resistant Drug	Tetracycline		Drug Info
Molecule Alteration	Expression	Up-regulation
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli		668369
Experiment for Molecule Alteration	DNA microarray hybridization assay
Experiment for Drug Resistance	Serial twofold agar dilutions assay
Mechanism Description	MgrA was an indirect regulator of tet38 expression. The mgrA tet38 double mutant became more susceptible to tetracycline than the wild-type parent strain.

References

Ref 1	MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus. J Bacteriol. 2005 Apr;187(7):2395-405. doi: 10.1128/JB.187.7.2395-2405.2005.