Molecule Information

General Information of the Molecule (ID: Mol01033)

Name	Oxytetracycline resistance efflux MFS transporter OtrB (OTRB) ,Streptomyces rimosus
Synonyms	otr(B); SRIM_038170; Oxytetracycline resistance efflux MFS transporter OtrB Click to Show/Hide
Molecule Type	Protein
Gene Name	otr(B)
Sequence	MSSANPGPAGTADQAGGAFTHRQILTAMSGLLLAVFLAALDQTVIATAMRTIADDLHGQT EQAWATTGYLIASVLAMPFYGKLSDIYGRKPMYLISIVVFIGGSVLCGTAGSMWELALFR AVQGLGGGGLMSLPTAVVADLAPVRERGRYFAFLQMAWVVASVAGPLAGGFFAEAGQVFG IDGWRWVFLLNVPLGLLALVTVRKALNLPHERREHRMDVLGAAALALFLVPLLIVAEQGR TWGWGSPAALALFALGAAGLAVFIPVELRRGDEAILPLGLFRRGSIALCSAVNFTIGVGI FGTVTTLPLFLQMVQGRTPTQAGLVVIPFMLGTIASQMVSGKLIASSGRFKKLAIVGLGS MAGALLAMATTGATTPMWGIVLIVLWLGVGIGLSQTVITLAMQNSAPKSQLGVANGASGL CRQIGGSTGIAVLFSVMFAVALGRLADLLHTPRYERLLTDPAITGDPANHRFLDMAESGQ GAGINLDDTSLLNGIDARLMQPVTDSFAHGFHIMFLAGGVVLLAGFVMTWFLRELQEETA PEEERPAESGAGAKNGPLPASDA Click to Show/Hide
Uniprot ID	L8EYT1_STRR1
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Actinobacteria Class: Actinomycetia Order: Streptomycetales Family: Streptomycetaceae Genus: Streptomyces Species: Streptomyces rimosus

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

Click to Show/Hide the Full List of Drugs

Tetracycline

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Streptomyces rimosus infection			[1]
Resistant Disease	Streptomyces rimosus infection [ICD-11: 1C43.12]		Disease Info
Resistant Drug	Tetracycline		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	Streptomyces rimosus strain		1927
Mechanism Description	The sequence of the tetracycline resistance gene designated tet347 from the tetracycline-producing organism Streptomyces rimosus (strain PG3) predicted a protein of 347 amino acids (GenBank accession no. M20370). The tcrC gene (also called tcr3; GenBank accession no. D38215) from chlorotetracycline-producing S. aureofaciens encoded a 512-residue putative tetracycline efflux protein which, starting at residue 222, was 43% identical to the Tet347 protein.

References

Ref 1	Revised sequence of OtrB (tet347) tetracycline efflux protein from Streptomyces rimosus. Antimicrob Agents Chemother. 1998 Nov;42(11):3050. doi: 10.1128/AAC.42.11.3050.