Molecule Information

General Information of the Molecule (ID: Mol00996)

• Name: Major facilitator superfamily MFS_1 (TETV) ,Mycolicibacterium smegmatis
• Synonyms: tetV; NCTC7017_03777; Tetracycline-resistance determinant tetV
• Molecule Type: Protein
• Gene Name: tetV
• Gene ID: 66736503
• Sequence:
  MRSPRPVAGWRVLAPFRIREYRLLIAAVTLSIFAEGMWSVVMALQVIAIDNDPASLSLVA
  TCLGVGLVAFVLVGGITADRINQRTIIIAVEVVNFVTVAVISALALLGVLKIWHMAVAAG
  ILGIAAAFFFPAYSAILPRILPPEQLLAANGVEGVVRPVFQRSVGPAVAGMVIGATMPSI
  GAVVVAVLFALGLALLVATRPPAQPASEHHERPHVLRDLREGFAFVLKTPWLLWTVLFAS
  MFVLVVLGPIEVLLPFIAQDRFADGARAYGFILAFFGIGSAMGALTVSSRRMPRRYLTTM
  MLMWGLGSIPLVIVGYTSSFPLMAAATFVIGVTDGAGMVIWGTLLQRRVPTEMLGRVSSL
  DFFVSLAFMPLSFAIVGPLSKVVSMEVIFATAGLVPVAIAAVAFTAARMHRDEVANPLL
• Uniprot ID: O31137_MYCSM

Kingdom: N.A.
Phylum: Actinobacteria
Class: Actinomycetia
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycolicibacterium
Species: Mycolicibacterium smegmatis

Type(s) of Resistant Mechanism of This Molecule

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Tetracycline

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Disease Class: Bacterial infection [1], [2], [3]

• Resistant Disease: Bacterial infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Tetracycline
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Mycobacterium abscessus OS11; 36809
• In Vitro Model: Mycobacterium abscessus OS13; 36809
• In Vitro Model: Mycobacterium fortuitum OS2/7; 1766
• In Vitro Model: Mycobacterium fortuitum OS21; 1766
• In Vitro Model: Mycobacterium fortuitum OS24; 1766
• In Vitro Model: Mycobacterium fortuitum OS25; 1766
• In Vitro Model: Mycobacterium fortuitum OS28; 1766
• In Vitro Model: Mycobacterium fortuitum OS30; 1766
• In Vitro Model: Mycobacterium fortuitum OS8; 1766
• In Vitro Model: Mycobacterium fortuitum OS9; 1766
• In Vitro Model: Mycobacterium fortuitum TR-1378; 1766
• In Vitro Model: Mycobacterium mucogenicum OS11; 56689
• In Vitro Model: Mycobacterium peregrinum OS2/8; 43304
• In Vitro Model: Mycobacterium smegmatis OS1; 1772
• Experiment for Molecule Alteration: Whole genome sequence assay
• Experiment for Drug Resistance: Disk diffusion test assay; E-strip test assay
• Mechanism Description: Tetracycline/multidrug efflux pumps Tet(V) and Tap may belong to this intrinsic resistome as they have been so far found only in certain RGM species.tet(V) and tap, both encode mycobacterial efflux pumps, including species where these genes have never been evidenced before.

References

• Ref 1: Update on acquired tetracycline resistance genes. FEMS Microbiol Lett. 2005 Apr 15;245(2):195-203. doi: 10.1016/j.femsle.2005.02.034.
• Ref 2: Tetracycline resistance and presence of tetracycline resistance determinants tet(V) and tap in rapidly growing mycobacteria from agricultural soils and clinical isolates. Microbes Environ. 2012;27(4):413-22. doi: 10.1264/jsme2.me12028. Epub 2012 May 17.
• Ref 3: Molecular cloning and functional analysis of a novel tetracycline resistance determinant, tet(V), from Mycobacterium smegmatis. Antimicrob Agents Chemother. 1998 Aug;42(8):1931-7. doi: 10.1128/AAC.42.8.1931.