General Information of the Molecule (ID: Mol00954)
Name
Enterococcal surface protein (ESP) ,Enterococcus faecalis
Synonyms
esp; Fragment
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Molecule Type
Protein
Gene Name
esp
Sequence
DSWLSDTNKKLIQNTYGTGYYYLQDIDGDGNPDDKEESGDTNPYIGKPELEEVYDVDTTV
KGKVFIHELAGTGHKAQLVDKEGTVLAEKTIAPNEKDGAPISDTVEFEFTGVDSSKLIAK
DELKIQIVSPGFDKPEEGSTVIKESPKAVDKQTVVVGFKPDA
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Uniprot ID
B7SF46_9ENTE
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Kingdom: N.A.
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus faecalis
Type(s) of Resistant Mechanism of This Molecule
  UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Chloramphenicol
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Disease Class: Enterococci faecium infection [1]
Resistant Disease Enterococci faecium infection [ICD-11: 1A00-1C4Z]
Resistant Drug Chloramphenicol
Molecule Alteration Expression
Inherence
Experimental Note Identified from the Human Clinical Data
In Vitro Model Enterococcus faecalis strain JH2-2 1320322
Enterococcus faecalis strain pIP1326g 1351
Enterococcus faecalis strain pIP655 1351
Enterococcus faecalis strain pIP683 1351
Enterococcus faecalis strain pIP687 1351
Enterococcus faecium strain pIP1182 1352
Enterococcus faecium strain pIP1535 1352
Enterococcus faecium strain pIP1538 1352
Enterococcus faecium strain pIP1539 1352
Enterococcus faecium strain pIP1687 1352
Enterococcus faecium strain pIP713 1352
Streptococci strain A451 36470
Streptococci strain A453 36470
Streptococci strain A456 36470
Streptococci strain B109 1319
Streptococci strain B117 1319
Streptococci strain B118 1319
Streptococci strain B120 1319
Streptococci strain B126 1319
Streptococci strain B127 1319
Streptococci strain BM132 1319
Streptococci strain BM137 36470
Streptococci strain BM140 1319
Streptococci strain G44 1320
Streptococci strain G52 1320
Streptococci strain G54 1320
Experiment for
Molecule Alteration
Southern blotting assay
Mechanism Description An assay based on the utilization of degenerate primers that enable enzymatic amplification of an internal fragment of cat genes known to be present in gram-positive cocci was developed to identify the genes encoding chloramphenicol resistance in streptococci and enterococci. The functionality of this system was illustrated by the detection of cat genes belonging to four different hydridization classes represented by the staphylococcal genes catpC221, catpC194, catpSCS7, and the clostridial gene catP, and by the characterization of a new streptococcal cat gene designated catS.
Disease Class: Enterococci faecalisc infection [1]
Resistant Disease Enterococci faecalisc infection [ICD-11: 1A00-1C4Z]
Resistant Drug Chloramphenicol
Molecule Alteration Expression
Inherence
Experimental Note Identified from the Human Clinical Data
In Vitro Model Enterococcus faecalis strain JH2-2 1320322
Enterococcus faecalis strain pIP1326g 1351
Enterococcus faecalis strain pIP655 1351
Enterococcus faecalis strain pIP683 1351
Enterococcus faecalis strain pIP687 1351
Enterococcus faecium strain pIP1182 1352
Enterococcus faecium strain pIP1535 1352
Enterococcus faecium strain pIP1538 1352
Enterococcus faecium strain pIP1539 1352
Enterococcus faecium strain pIP1687 1352
Enterococcus faecium strain pIP713 1352
Streptococci strain A451 36470
Streptococci strain A453 36470
Streptococci strain A456 36470
Streptococci strain B109 1319
Streptococci strain B117 1319
Streptococci strain B118 1319
Streptococci strain B120 1319
Streptococci strain B126 1319
Streptococci strain B127 1319
Streptococci strain BM132 1319
Streptococci strain BM137 36470
Streptococci strain BM140 1319
Streptococci strain G44 1320
Streptococci strain G52 1320
Streptococci strain G54 1320
Experiment for
Molecule Alteration
Southern blotting assay
Mechanism Description An assay based on the utilization of degenerate primers that enable enzymatic amplification of an internal fragment of cat genes known to be present in gram-positive cocci was developed to identify the genes encoding chloramphenicol resistance in streptococci and enterococci. The functionality of this system was illustrated by the detection of cat genes belonging to four different hydridization classes represented by the staphylococcal genes catpC221, catpC194, catpSCS7, and the clostridial gene catP, and by the characterization of a new streptococcal cat gene designated catS.
References
Ref 1 Study of heterogeneity of chloramphenicol acetyltransferase (CAT) genes in streptococci and enterococci by polymerase chain reaction: characterization of a new CAT determinant. Antimicrob Agents Chemother. 1993 Dec;37(12):2593-8. doi: 10.1128/AAC.37.12.2593.

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