Molecule Information

General Information of the Molecule (ID: Mol00907)

Name	Dipeptide and tripeptide permease A (DTPA) ,Escherichia coli
Synonyms	tppB; ydgR; b1634; JW1626 Click to Show/Hide
Molecule Type	Protein
Gene Name	dtpA
Gene ID	58463902
Sequence	MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSI TLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMA AIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYGWS VAFALSVVGLLITIVNFAFCQRWVKQYGSKPDFEPINYRNLLLTIIGVVALIAIATWLLH NQEVARMALGVVAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLN FFAIRNVEHSILGLAVEPEQYQALNPFWIIIGSPILAAIYNKMGDTLPMPTKFAIGMVMC SGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIM GSWFLTTAGANLIGGYVAGMMAVPDNVTDPLMSLEVYGRVFLQIGVATAVIAVLMLLTAP KLHRMTQDDAADKAAKAAVA Click to Show/Hide
Function	Proton-dependent permease that transports di- and tripeptides as well as structurally related peptidomimetics such as aminocephalosporins into the cell. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discriminates dipeptides on the basis of the position of charges within the substrate. Click to Show/Hide
Uniprot ID	DTPA_ECOLI
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Escherichia Species: Escherichia coli

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Chloramphenicol

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Escherichia coli infection			[1]
Sensitive Disease	Escherichia coli infection [ICD-11: 1A03.0]		Disease Info
Sensitive Drug	Chloramphenicol		Drug Info
Molecule Alteration	Expression	Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	Escherichia coli BL21(DE3)pLysS cell		866768
Experiment for Molecule Alteration	Western blotting analysis
Experiment for Drug Resistance	Determination of MICs assay
Mechanism Description	POT YdgR facilitates Cam uptake in E. coli.

References

Ref 1	The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells. J Biol Chem. 2018 Jan 19;293(3):1007-1017. doi: 10.1074/jbc.M117.805960. Epub 2017 Nov 17.