Molecule Information

General Information of the Molecule (ID: Mol00884)

Name	Cytochrome P450 sterol 14 alpha-demethylase (CYP51) ,Histoplasma capsulatum
Synonyms	CYP51; I7I51_04085; Cytochrome P450 sterol 14 alpha-demethylase Click to Show/Hide
Molecule Type	Protein
Gene Name	CYP51
Sequence	MSWFTIGTFGVLAFVAAVTLNLVYQLLFRFLNKTRPPLVFHWIPFLGSTIRYRTDPYKFF FSCRQKEASRLFQHGDIFTFVLLGRPTTVYLGIKGNEFILNGKLKDVNAEEVYGPLTTPV FGPDVVYDCPNSKLIEQKKFIKYGLTQAALESHVPLIEKEVMDYLDSSPNFLGASGEVDI SAVMAEITIFTAGSALQGEEVRSKLTTEFAVLYHDLDKGFSPINFMLPWAPLPHNKKRDA AHTLMHAIYLDIIEKRRRAARNANGSQTQDMIENLMQCTYKNGQKLPDKEIANIMISLLM AGQHSSSTTSSWIMLHLASEPAVVEQLYQEQLDNLPRTGPNGSLGPLQYGDLNRLPLHRN VIRETLRLHTSIHSLLRKVMNPMPVAGTPYVIPPSHVVLSAPGVTALSDEYFPNPTMWDP NRWETQEPKVDEKEDMVDYGYGTISKGTSSPYLPFGAGRHRCIGEKFAYVNLTVIVAIMV RHLQFSNIGGKTGVPRTDYSSMFSAPMKPARINWKRRTAKSG Click to Show/Hide
Uniprot ID	A0A8A1M600_AJECA
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Fungi Phylum: Ascomycota Class: Eurotiomycetes Order: Onygenales Family: Ajellomycetaceae Genus: Histoplasma Species: Histoplasma capsulatum

Type(s) of Resistant Mechanism of This Molecule

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Voriconazole

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)		Click to Show/Hide
Disease Class: Histoplasmosis			[1]
Resistant Disease	Histoplasmosis [ICD-11: 1F2A.0]		Disease Info
Resistant Drug	Voriconazole		Drug Info
Molecule Alteration	Missense mutation	p.Y136F
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Histoplasma capsulatum strain		5037
Experiment for Molecule Alteration	DNA sequencing assay
Experiment for Drug Resistance	NCCLS method assay
Mechanism Description	In summary, fluconazole treatment of disseminated histoplasmosis in patients with AIDS was associated with induction of resistance to fluconazole and, to a lesser extent, to voriconazole. And the changes in susceptibility were due to tagert alterations which a single amino acid substitution in CYP51p at Y136 appeared to be responsible for the reduction in susceptibility seen in the relapse isolate.

References

Ref 1	Activity of newer triazoles against Histoplasma capsulatum from patients with AIDS who failed fluconazole. J Antimicrob Chemother. 2006 Jun;57(6):1235-9. doi: 10.1093/jac/dkl133. Epub 2006 Apr 20.