General Information of the Molecule (ID: Mol00875)
Name
Chloramphenicol acetyltransferase 2 (CATII) ,Haemophilus influenzae
Synonyms
Chloramphenicol acetyltransferase II; CAT-II
    Click to Show/Hide
Molecule Type
Protein
Gene Name
cat-IIH
Sequence
MNFTRIDLNTWNRREHFALYRQQIKCGFSLTTKLDITAFRTALAETDYKFYPVMIYLISR
VVNQFPEFRMAMKDNALIYWDQTDPVFTVFHKETETFSALFCRYCPDISEFMAGYNAVMA
EYQHNTALFPQGALPENHLNISSLPWVSFDGFNLNITGNDDYFAPVFTMAKFQQEDNRVL
LPVSVQVHHAVCDGFHAARFINTLQMMCDNILK
    Click to Show/Hide
Function
This enzyme is an effector of chloramphenicol resistance in bacteria.
    Click to Show/Hide
Uniprot ID
CAT2_HAEIF
        Click to Show/Hide the Complete Species Lineage
Kingdom: N.A.
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pasteurellales
Family: Pasteurellaceae
Genus: Haemophilus
Species: Haemophilus influenzae
Type(s) of Resistant Mechanism of This Molecule
  DISM: Drug Inactivation by Structure Modification
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
Click to Show/Hide the Full List of Drugs
Chloramphenicol
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Drug Inactivation by Structure Modification (DISM) Click to Show/Hide
Disease Class: Haemophilus influenzae infection [1]
Resistant Disease Haemophilus influenzae infection [ICD-11: 1A00-1C4Z]
Resistant Drug Chloramphenicol
Molecule Alteration Expression
Inherence
Experimental Note Discovered Using In-vivo Testing Model
In Vitro Model Escherichia coli strain JM 101 562
Mechanism Description Bacterial resistance to the antibiotic chloramphenicol, an inhibitor of the peptidyltransferase activity of prokaryotic ribosomes, is commonly conferred by the enzyme chloramphenicol acetyltransferase (CAT,EC2.3.1.28). The enzyme catalyses transfer of the acetyl group of acetyl-CoA to the primary (C-3) hydroxy group of chloramphenicol, yielding 3-acetylchloramphenicol, which fails to bind to bacterial ribosomes. Three classes of CAT variant have been characterized among Gram-negative bacteria, designated typesI, II and III.
References
Ref 1 Nucleotide sequences of genes encoding the type II chloramphenicol acetyltransferases of Escherichia coli and Haemophilus influenzae, which are sensitive to inhibition by thiol-reactive reagents. Biochem J. 1990 Dec 1;272(2):505-10. doi: 10.1042/bj2720505.

If you find any error in data or bug in web service, please kindly report it to Dr. Sun and Dr. Zhang.