Molecule Information

General Information of the Molecule (ID: Mol00873)

• Name: Chloramphenicol acetyltransferase (CAT) ,Enterococcus faecalis
• Synonyms: CGZ46_14915; EY666_15625
• Molecule Type: Protein
• Gene Name: catA
• Sequence:
  MTFNIINLETWDRKEYFNHYFNQQTTFSVTKEFDITLLKSMIKNKGYKLYPALIYIIVNI
  INQNKVFRTGINSEGNLGYWDKLNPLYTVFNKETEKFSNIWTESNVSFNSFYNSYKSDLL
  EYKDKNEMFPKKPIPENTVPISMIPWIDFSSFNLNIGNNSRFLLPIITMGKFYSKNNKIY
  LPVSLQVHHAVCDGYHASLFMSEFQNMVDSVNEWI
• Function: This enzyme is an effector of chloramphenicol resistance in bacteria.
• Uniprot ID: A0A1J6XFK8_ENTFL

Kingdom: N.A.
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus faecalis

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Chloramphenicol

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Enterococcus faecalis infection [1]

• Resistant Disease: Enterococcus faecalis infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Chloramphenicol
• Molecule Alteration: Expression; Inherence
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Enterococcus faecalis JH2-2; 1351
• In Vitro Model: Escherichia coli strain XL-1 Blue; 562
• In Vitro Model: Enterococcus faecalis ESP91; 1351
• In Vitro Model: Enterococcus faecalis FO1; 1351
• In Vitro Model: Enterococcus faecalis FO5; 1351
• In Vitro Model: Enterococcus faecalis JHBURE16-1; 1351
• In Vitro Model: Enterococcus faecalis JHBURE16-2; 1351
• In Vitro Model: Enterococcus faecalis JHBURE16-3; 1351
• In Vitro Model: Enterococcus faecalis JHBURE8-1; 1351
• In Vitro Model: Enterococcus faecalis JHBURE8-2; 1351
• In Vitro Model: Enterococcus faecalis JHBURE8-3; 1351
• In Vitro Model: Enterococcus faecalis JHRE25-2; 1351
• In Vitro Model: Enterococcus faecalis JHRE25-3; 1351
• In Vitro Model: Enterococcus faecalis RE17; 1351
• In Vitro Model: Enterococcus faecalis RE25; 1351
• In Vitro Model: Enterococcus faecalis RE38; 1351
• In Vitro Model: Enterococcus faecalis RE44; 1351
• In Vitro Model: Enterococcus faecalis RE52; 1351
• In Vitro Model: Enterococcus faecium FI1; 1352
• In Vitro Model: Escherichia coli CM1; CM25
• In Vitro Model: Escherichia coli CM2; CM25
• In Vitro Model: Escherichia coli CM25; 562
• In Vitro Model: Lactococcus lactis susp. cremoris AC1; 1359
• In Vitro Model: Lactococcus lactis susp. lactis biovar. diacetylactis Bu2-60; 44688
• In Vitro Model: Lactococcus lactis susp. lactis biovar. diacetylactis Bu2-60/pAMb1; 44688
• In Vitro Model: Lactococcus lactis susp. lactis biovar. diacetylactis Bu2-60/pIP501; 44688
• In Vitro Model: Lactococcus lactis susp. lactis biovar. diacetylactis Bu2-60/pRE39; 44688
• In Vitro Model: Lactococcus lactis susp. lactis biovar. diacetylactis BURE25-11; 44688
• In Vitro Model: Lactococcus lactis susp. lactis biovar. diacetylactis BURE25-12; 44688
• In Vitro Model: Lactococcus lactis susp. lactis biovar. diacetylactis BURE25-15; 44688
• In Vitro Model: Lactococcus lactis susp. lactis biovar. diacetylactis BURE25-16; 44688
• In Vitro Model: Lactococcus lactis susp. lactis biovar. diacetylactis BURE25-3; 44688
• In Vitro Model: Lactococcus lactis susp. lactis biovar. diacetylactis BURE25-6; 44688
• In Vitro Model: Lactococcus lactis susp. lactis biovar. diacetylactis BURE25-7; 44688
• In Vitro Model: Lactococcus lactis susp. lactis biovar. diacetylactis BURE25-8; 44688
• In Vitro Model: Lactococcus lactis susp. lactis biovar. diacetylactis BURE25-9; 44688
• In Vitro Model: Listeria innocua L19; 1642
• In Vitro Model: Listeria innocua L191; 1642
• In Vitro Model: Listeria innocua L193; 1642
• In Vitro Model: Staphylococcus xylosus strains VF5; 1288
• Experiment for Molecule Alteration: DNA hybridizations assay
• Experiment for Drug Resistance: Microdilution test assay
• Mechanism Description: Two antibiotic-resistance genes are present on this 30.5-kb region, a chloramphenicol acetyltransferase gene (orf10) and a 23S rRNA methyltransferase gene (orf14). Both genes have been shown to be active in E. faecalis RE25 and in its transconjugants.

References

• Ref 1: Sequence of the 50-kb conjugative multiresistance plasmid pRE25 from Enterococcus faecalis RE25. Plasmid. 2001 Nov;46(3):170-87. doi: 10.1006/plas.2001.1544.