Molecule Information

General Information of the Molecule (ID: Mol00872)

• Name: Chloramphenicol acetyltransferase (CAT) ,Brevibacillus brevis
• Molecule Type: Protein
• Gene Name: catV
• Sequence:
  MKFQRIDLDNWSRRSYFEHYLNRVNCTFSMTANIDITELLPALRQKEMKLYPAFLYMVTN
  AVNAHREFRTSFHADGELGYWESMIPSYTFFHQDDQTFSTMWTEFADEFPVFYQNYVADM
  KKYGDNKGLVAKELEPPYTFPVSCIPWVSFSGFNLNISGDGRYLLPIITSGKYFGQEGKT
  LLPVSLQVHHAVCDGYHASLFIHDLQKWATNYKEWLGVE
• Function: This enzyme is an effector of chloramphenicol resistance in bacteria.
• Uniprot ID: A0A291R8R6_BREBE

Kingdom: N.A.
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Paenibacillaceae
Genus: Brevibacillus
Species: Brevibacillus brevis

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Chloramphenicol

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Bacterial infection [1]

• Resistant Disease: Bacterial infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Chloramphenicol
• Molecule Alteration: Expression; Inherence
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Paenibacillus sp. LC231; 1120679
• Mechanism Description: Redundant chloramphenicol (catV and clbB) and kanamycin (ant(4')-lc and aac(6')-35) resistance are common in Paenibacillaceae, especially within Brevibacillus and Aneurinibacillus.

References

• Ref 1: The complex resistomes of Paenibacillaceae reflect diverse antibiotic chemical ecologies. ISME J. 2018 Mar;12(3):885-897. doi: 10.1038/s41396-017-0017-5. Epub 2017 Dec 19.