General Information of the Molecule (ID: Mol00871)
Name
Chloramphenicol acetyltransferase (CAT) ,Proteus mirabilis
Synonyms
CEP63_016285
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Molecule Type
Protein
Gene Name
catA
Sequence
MNYEKINLEQWNRKEHFLHYRHNLQCGFSLTTKIDITVLKTVLAKNNLKLYPAMIYLIAK
TVNSYSESRMAIKDDELVIWDYINPVYTIFHPETETFSELWSEYVEDWHSFLEGYNQDYQ
KYKDNLSLSAKSNFPENHFCISMIPWISFDGFNLNVANVKDYFPPIFTMGKYTQQSDNFL
LPISIQVHHATCDGFHIARMINKLQELCDGFSG
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Function
This enzyme is an effector of chloramphenicol resistance in bacteria.
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Uniprot ID
A0A2J9LAW3_PROMI
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Kingdom: N.A.
Phylum: Actinobacteria
Class: Actinomycetia
Order: Streptomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: Streptomyces actuosus
Type(s) of Resistant Mechanism of This Molecule
  DISM: Drug Inactivation by Structure Modification
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Chloramphenicol
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Drug Inactivation by Structure Modification (DISM) Click to Show/Hide
Disease Class: Proteus mirabilis infection [1]
Resistant Disease Proteus mirabilis infection [ICD-11: 1A00-1C4Z]
Resistant Drug Chloramphenicol
Molecule Alteration Expression
Inherence
Experimental Note Discovered Using In-vivo Testing Model
In Vitro Model Escherichia coli strain JM103 83333
Proteus mirabilis strain PM13 584
Proteus mirabilis strain PM2 584
Experiment for
Molecule Alteration
RNA-DNA hybridizations assay
Mechanism Description In Proteus mirabilis PM13 chloramphenicol resistance is mediated by the cat gene, a single copy of which is present in both resistant and sensitive isolates and which reverts at a high frequency. RNA measurements show an about 8.5-fold increase in cat-specific mRNA in cells expressing the resistance phenotype as compared with those which are sensitive to chloramphenicol.
References
Ref 1 Nucleotide sequence analysis of the cat gene of Proteus mirabilis: comparison with the type I (Tn9) cat gene. J Bacteriol. 1985 Oct;164(1):123-9. doi: 10.1128/jb.164.1.123-129.1985.

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