Molecule Information
General Information of the Molecule (ID: Mol00871)
Name |
Chloramphenicol acetyltransferase (CAT)
,Proteus mirabilis
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Synonyms |
CEP63_016285
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Molecule Type |
Protein
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Gene Name |
catA
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Sequence |
MNYEKINLEQWNRKEHFLHYRHNLQCGFSLTTKIDITVLKTVLAKNNLKLYPAMIYLIAK
TVNSYSESRMAIKDDELVIWDYINPVYTIFHPETETFSELWSEYVEDWHSFLEGYNQDYQ KYKDNLSLSAKSNFPENHFCISMIPWISFDGFNLNVANVKDYFPPIFTMGKYTQQSDNFL LPISIQVHHATCDGFHIARMINKLQELCDGFSG Click to Show/Hide
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Function |
This enzyme is an effector of chloramphenicol resistance in bacteria.
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Uniprot ID | |||||
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Type(s) of Resistant Mechanism of This Molecule
DISM: Drug Inactivation by Structure Modification
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
Chloramphenicol
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Drug Inactivation by Structure Modification (DISM) | ||||
Disease Class: Proteus mirabilis infection | [1] | |||
Resistant Disease | Proteus mirabilis infection [ICD-11: 1A00-1C4Z] | |||
Resistant Drug | Chloramphenicol | |||
Molecule Alteration | Expression | Inherence |
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Experimental Note | Discovered Using In-vivo Testing Model | |||
In Vitro Model | Escherichia coli strain JM103 | 83333 | ||
Proteus mirabilis strain PM13 | 584 | |||
Proteus mirabilis strain PM2 | 584 | |||
Experiment for Molecule Alteration |
RNA-DNA hybridizations assay | |||
Mechanism Description | In Proteus mirabilis PM13 chloramphenicol resistance is mediated by the cat gene, a single copy of which is present in both resistant and sensitive isolates and which reverts at a high frequency. RNA measurements show an about 8.5-fold increase in cat-specific mRNA in cells expressing the resistance phenotype as compared with those which are sensitive to chloramphenicol. |
References
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