Molecule Information

General Information of the Molecule (ID: Mol00866)

• Name: Chloramphenicol acetyltransferase (CAT) ,Vibrio anguillarum
• Synonyms: CAT
• Molecule Type: Protein
• Gene Name: cat
• Sequence:
  MEFRLVDLKTWKRKEYFTHYFESVPCTYSMTVKLDITTIKTGKAKLYPALLYAVSTVVNR
  HEEFRMTVDDEGQIGIFSEMMPCYTIFQKDTEMFSNIWTEYIGDYTEFCKQYEKDMQQYG
  ENKGMMAKPNPPVNTFPVSMIPWTTFEGFNLNLQKGYGYLLPIFTFGRYYEENGKYWIPL
  SIQVHHAVCDGFHTCRFINELQDVIQSLQNHGGDEE
• Function: This enzyme is an effector of chloramphenicol resistance in bacteria.
• Uniprot ID: CAT_VIBAN

Kingdom: N.A.
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: Vibrio anguillarum

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Chloramphenicol

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Vibrio anguillarum infection [1]

• Resistant Disease: Vibrio anguillarum infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Chloramphenicol
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Escherichia coli strain CSR603; 562
• In Vitro Model: Escherichia coli strain HBIOI; 562
• Experiment for Molecule Alteration: Whole genome sequence assay
• Mechanism Description: The chloramphenicol resistant genes (cat) have been found in various bacterial chromosomes, in antibioticresistant (R) plasmids and sometimes within a transposable element.

References

• Ref 1: Cloning and nucleotide sequence analysis of a chloramphenicol acetyltransferase gene from Vibrio anguillarum. Microbiol Immunol. 1992;36(7):695-705. doi: 10.1111/j.1348-0421.1992.tb02072.x.