Molecule Information

General Information of the Molecule (ID: Mol00864)

Name	Chloramphenicol acetyltransferase (CAT) ,Agrobacterium tumefaciens
Synonyms	Atu4738; AGR_L_286 Click to Show/Hide
Molecule Type	Protein
Gene Name	cat
Sequence	MENYFESPFRGITLDKQVKSPNLVVGKYSYYSGYYHGHSFEDCARYLLPDEGADRLVIGS FCSIGSGAAFIMAGNQGHRNEWISTFPFFFMPEVPEFENAANGYLPAGDTVIGNDVWIGS EAIIMPGITVGDGAVIGTRALVTKDVEPYAIVGGNPAKTIRKRFDDDSIALLLEMKWWGW PAERLKAAMPLMTSGNVAALYRFWRSDSL Click to Show/Hide
Function	This enzyme is an effector of chloramphenicol resistance in bacteria. Click to Show/Hide
Uniprot ID	CAT4_AGRFC
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Proteobacteria Class: Alphaproteobacteria Order: Hyphomicrobiales Family: Rhizobiaceae Genus: Agrobacterium Species: Agrobacterium tumefaciens

Type(s) of Resistant Mechanism of This Molecule

DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Chloramphenicol

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Drug Inactivation by Structure Modification (DISM)		Click to Show/Hide
Disease Class: Agvobactevitlm tumefuciens infection			[1]
Resistant Disease	Agvobactevitlm tumefuciens infection [ICD-11: 1A00-1C4Z]		Disease Info
Resistant Drug	Chloramphenicol		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	Agrobacterium tumefaciens strain C58		358
	Escherichia coli strain JM101		83333
Experiment for Molecule Alteration	Enzyme assay
Mechanism Description	The nucleotide sequence of a chloramphenicol-resistance (CmR) determinant from the Gram- soil bacterium Agrobacterium tumefaciens was determined, and its gene product was identified as Cm acetyltransferase (CAT). Comparison of the amino acid sequences of the A. tumefaciens CAT and various CAT proteins of Gram+ and Gram- origin shows no homology between this and the other enzymes.

References

Ref 1	Nucleotide sequence analysis of a chloramphenicol-resistance determinant from Agrobacterium tumefaciens and identification of its gene product. Gene. 1991 Feb 1;98(1):113-6. doi: 10.1016/0378-1119(91)90112-o.