Molecule Information

General Information of the Molecule (ID: Mol00825)

• Name: Beta-lactamase (BLA) ,Klebsiella pneumoniae
• Synonyms: bla_4; blaOXA-48; G5637_27540; GPZ86_28000; KPE71T_00045; SAMEA3727643_05844
• Molecule Type: Protein
• Gene Name: bla
• Sequence:
  MRVLALSAVFLVASIIGMPAVAKEWQENKSWNAHFTEHKSQGVVVLWNENKQQGFTNNLK
  RANQAFLPASTFKIPNSLIALDLGVVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVV
  PVYQEFARQIGEARMSKMLHAFDYGNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNK
  LHVSERSQRIVKQAMLTEANGDYIIRAKTGYSTRIEPKIGWWVGWVELDDNVWFFAMNMD
  MPTSDGLGLRQAITKEVLKQEKIIP
• Uniprot ID: Q6XEC0_KLEPN

Kingdom: N.A.
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella pneumoniae

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 2 drug(s) in total

Penicillin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Klebsiella pneumoniae infection [1]

• Resistant Disease: Klebsiella pneumoniae infection [ICD-11: CA40.1]
• Resistant Drug: Penicillin
• Molecule Alteration: Expression; Inherence
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Klebsiella pneumoniae 11978; 573
• Experiment for Molecule Alteration: DNA sequencing and protein assay
• Experiment for Drug Resistance: Agar dilution assay
• Mechanism Description: The Beta-lactamase OXA-48 hydrolyzed imipenem at a high level.

Imipenem

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Klebsiella pneumoniae infection [1]

• Resistant Disease: Klebsiella pneumoniae infection [ICD-11: CA40.1]
• Resistant Drug: Imipenem
• Molecule Alteration: Expression; Inherence
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Klebsiella pneumoniae 11978; 573
• Experiment for Molecule Alteration: DNA sequencing and protein assay
• Experiment for Drug Resistance: Agar dilution assay
• Mechanism Description: The Beta-lactamase OXA-48 hydrolyzed imipenem at a high level.

References

• Ref 1: Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob Agents Chemother. 2004 Jan;48(1):15-22. doi: 10.1128/AAC.48.1.15-22.2004.