Molecule Information

General Information of the Molecule (ID: Mol00813)

Name	Bcr/CflA family efflux transporter (BCML) ,Klebsiella aerogenes
Molecule Type	Protein
Gene Name	cmlB
Sequence	MRSKNCNWRYSLAVTVLLLSPFDLLASLGMDMYLPAVPFMPHALGTTAGTIQLTLTTYLV MIGAGQLLFGPLSDRLGRRPVLLAGGAAYVAASIGLVVTSSAGVFLGFRILQACGASACL VATFATVRDIYAGRKESNVIYGLLGSMLAMVPAIGPLLGAVIDTWFGWRAIFAFLGLGMI AALTAAWRLWPETRVQRPAALQWSQLLLPIKHLNFWLYTVCYAAGMGSFFVFFSIAPGLM MGRQGMSQFGFSLLFATVAIAMMLAARFMGRVIAKWGSLSALRMGMGCLIAGAVLLVITE LWIPQSVLGFIAPMWLVGVGVATAVSVAPNGALRGFDHIAGAVTAVYFCLGGLLLGSVGT LIISLLPRDTAWPVIAYCLVLATIVLGLSCVSRARDLRGHGEYDAVART Click to Show/Hide
Uniprot ID	Q9X2P0_KLEAE
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Kingdom: N.A. Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Klebsiella Species: Klebsiella aerogenes

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Chloramphenicol

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Enterobacter aerogenes infection			[1]
Resistant Disease	Enterobacter aerogenes infection [ICD-11: 1A00-1C4Z]		Disease Info
Resistant Drug	Chloramphenicol		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli JM83		562
	Enterobacter aerogenes strain		548
	Enterobacter aerogenes strain BM2688		548
	Enterobacter aerogenes strain BM2688-1		548
	Escherichia coli strain J5-3		562
Experiment for Molecule Alteration	Southern hybridization assay
Experiment for Drug Resistance	Disk diffusion assay
Mechanism Description	A putative GTG initiation codon at position 718 was preceded at 8 bp by a RBS-like sequence. This coding sequence, designated cmlA2, shared 83.7% identity with the cmlA1 gene of the class 1 integron In4 in Tn1696 which confers nonenzymatic chloramphenicol resistance.

References

Ref 1	Characterization of In40 of Enterobacter aerogenes BM2688, a class 1 integron with two new gene cassettes, cmlA2 and qacF. Antimicrob Agents Chemother. 1998 Oct;42(10):2557-63. doi: 10.1128/AAC.42.10.2557.