Molecule Information

General Information of the Molecule (ID: Mol00783)

Name	Aminoglycoside 3'-phosphotransferase (A3AP) ,Streptomyces ribosidificus
Synonyms	APH(3'); Kanamycin kinase; Ribostamycin phosphotransferase Click to Show/Hide
Molecule Type	Protein
Gene Name	rph
Sequence	MESTLRRTYPHHTWHLVNEGDSGAFVYRLTGHGPELYAKIAPRTPENSAFHLDGEADRLD WLARHGISVPRVVERGADDTTAWLVTEAVPGAAASEEWPEDERAAVVDAIAEMARTLHEL PVSECPFDRRLDVTGEARHNVREGLVDLDDLQEEPAGWTGDQLLAELDLTRPEKEDLVVC HGDLCPNNVLLDPETHRITGLIDVGRLRLATCHADLALAARELAIDEDPWFGPAYAERFL ERYGAHHVDQEKMAFYQLLDEFF Click to Show/Hide
Function	Resistance to kanamycin and structurally-related aminoglycosides, including amikacin. Click to Show/Hide
Uniprot ID	KKA9_STRRI
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Actinobacteria Class: Actinomycetia Order: Streptomycetales Family: Streptomycetaceae Genus: Streptomyces Species: Streptomyces ribosidificus

Type(s) of Resistant Mechanism of This Molecule

DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Ribostamycin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Drug Inactivation by Structure Modification (DISM)		Click to Show/Hide
Disease Class: Streptomyces ribosidificus infection			[1]
Resistant Disease	Streptomyces ribosidificus infection [ICD-11: 1C43.14]		Disease Info
Resistant Drug	Ribostamycin		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Streptomyces lividans strain 66		1200984
	Escherichia coli strain DH-SCY		562
	Escherichia coli strain k-12		83333
	Streptomyces hygroscopicus strain SF1084		1912
	Streptomyces ribosidificus strain SF733		80859
Experiment for Molecule Alteration	Northern hybridization assay
Experiment for Drug Resistance	Gradient-plate technique of Szybalski assay
Mechanism Description	The rph gene conferring ribostamycin 3'-O-phosphorylation was isolated from a ribostamycin producer, S. ribosidifcus SF733.

References

Ref 1	Nucleotide sequence of the ribostamycin phosphotransferase gene and of its control region in Streptomyces ribosidificus. Gene. 1988 Sep 7;68(2):285-96. doi: 10.1016/0378-1119(88)90031-5.