General Information of the Molecule (ID: Mol00109)
Name
Melanoma-associated antigen 12 (MAGEA12) ,Homo sapiens
Synonyms
Cancer/testis antigen 1.12; CT1.12; MAGE-12 antigen; MAGE12F antigen; MAGE12
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Molecule Type
Protein
Gene Name
MAGEA12
Gene ID
4111
Location
chrX:152733757-152737669[+]
Sequence
MPLEQRSQHCKPEEGLEAQGEALGLVGAQAPATEEQETASSSSTLVEVTLREVPAAESPS
PPHSPQGASTLPTTINYTLWSQSDEGSSNEEQEGPSTFPDLETSFQVALSRKMAELVHFL
LLKYRAREPFTKAEMLGSVIRNFQDFFPVIFSKASEYLQLVFGIEVVEVVRIGHLYILVT
CLGLSYDGLLGDNQIVPKTGLLIIVLAIIAKEGDCAPEEKIWEELSVLEASDGREDSVFA
HPRKLLTQDLVQENYLEYRQVPGSDPACYEFLWGPRALVETSYVKVLHHLLKISGGPHIS
YPPLHEWAFREGEE
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Function
Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.
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Uniprot ID
MAGAC_HUMAN
Ensembl ID
ENSG00000213401
HGNC ID
HGNC:6799
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Drug
Approved Drug(s)
2 drug(s) in total
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Cisplatin
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Disease Class: Medulloblastoma [1]
Sensitive Disease Medulloblastoma [ICD-11: 2A00.10]
Sensitive Drug Cisplatin
Molecule Alteration Expression
Down-regulation
Experimental Note Identified from the Human Clinical Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
p53 signaling pathway Activation hsa04115
In Vitro Model UW228 cells Brain Homo sapiens (Human) CVCL_8585
R262 cells Bone marrow Homo sapiens (Human) CVCL_VU83
R300 cells Bone marrow Homo sapiens (Human) CVCL_VU84
UW426 cells Bone marrow Homo sapiens (Human) CVCL_DH82
Experiment for
Molecule Alteration
Western blotting analysis
Experiment for
Drug Resistance
MTS assay
Mechanism Description The repression of MAGE-A by miR-34a results in increased expression of p53 thus lead to resistance.
Mitomycin
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Disease Class: Medulloblastoma [1]
Sensitive Disease Medulloblastoma [ICD-11: 2A00.10]
Sensitive Drug Mitomycin
Molecule Alteration Expression
Down-regulation
Experimental Note Identified from the Human Clinical Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
p53 signaling pathway Activation hsa04115
In Vitro Model UW228 cells Brain Homo sapiens (Human) CVCL_8585
R262 cells Bone marrow Homo sapiens (Human) CVCL_VU83
R300 cells Bone marrow Homo sapiens (Human) CVCL_VU84
UW426 cells Bone marrow Homo sapiens (Human) CVCL_DH82
Experiment for
Molecule Alteration
Western blotting analysis
Experiment for
Drug Resistance
MTS assay
Mechanism Description The repression of MAGE-A by miR-34a results in increased expression of p53 thus lead to resistance.
Disease- and Tissue-specific Abundances of This Molecule
ICD Disease Classification 02
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Brain cancer [ICD-11: 2A00]
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Differential expression of molecule in resistant diseases
The Studied Tissue Nervous tissue
The Specified Disease Brain cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 4.10E-16; Fold-change: 1.21E-01; Z-score: 4.07E-01
Molecule expression in the diseased tissue of patients
Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances Click to View the Clearer Original Diagram
The Studied Tissue Brainstem tissue
The Specified Disease Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 2.53E-01; Fold-change: 2.54E-01; Z-score: 1.42E+00
Molecule expression in the diseased tissue of patients
Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances Click to View the Clearer Original Diagram
The Studied Tissue White matter
The Specified Disease Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 6.46E-02; Fold-change: -2.42E-01; Z-score: -4.59E-01
Molecule expression in the diseased tissue of patients
Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances Click to View the Clearer Original Diagram
The Studied Tissue Brainstem tissue
The Specified Disease Neuroectodermal tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.63E-02; Fold-change: -1.65E-01; Z-score: -7.88E-01
Molecule expression in the diseased tissue of patients
Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances Click to View the Clearer Original Diagram
Tissue-specific Molecule Abundances in Healthy Individuals
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References
Ref 1 miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma. Neuro Oncol. 2011 Feb;13(2):165-75. doi: 10.1093/neuonc/noq179. Epub 2010 Dec 22.

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