Drug (ID: DG01904) and It's Reported Resistant Information
Name
EAP Protocol
Synonyms
EAP Protocol
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Target . NOUNIPROTAC [1]
Type(s) of Resistant Mechanism of This Drug
  UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
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Gastric cancer [ICD-11: 2B72]
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R282L (c.845G>T)
Sensitive Disease Gastric adenocarcinoma [ICD-11: 2B72.0]
Experimental Note Identified from the Human Clinical Data
In Vitro Model Stomach N.A.
Experiment for
Molecule Alteration
Immunoblotting analysis
Mechanism Description The missense mutation p.R282L (c.845G>T) in gene TP53 cause the sensitivity of EAP Protocol by unusual activation of pro-survival pathway
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R175H (c.524G>A)
Sensitive Disease Gastric adenocarcinoma [ICD-11: 2B72.0]
Experimental Note Identified from the Human Clinical Data
In Vitro Model Stomach N.A.
Experiment for
Molecule Alteration
Immunoblotting analysis
Mechanism Description The missense mutation p.R175H (c.524G>A) in gene TP53 cause the sensitivity of EAP Protocol by unusual activation of pro-survival pathway
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R213P (c.638G>C)
Sensitive Disease Gastric adenocarcinoma [ICD-11: 2B72.0]
Experimental Note Identified from the Human Clinical Data
In Vitro Model Stomach N.A.
Experiment for
Molecule Alteration
Immunoblotting analysis
Mechanism Description The missense mutation p.R213P (c.638G>C) in gene TP53 cause the sensitivity of EAP Protocol by unusual activation of pro-survival pathway
References
Ref 1 Alterations in p53 predict response to preoperative high dose chemotherapy in patients with gastric cancerMol Pathol. 2003 Oct;56(5):286-92. doi: 10.1136/mp.56.5.286.

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