Drug Information
Drug (ID: DG01904) and It's Reported Resistant Information
Name |
EAP Protocol
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Synonyms |
EAP Protocol
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Target | . | NOUNIPROTAC | [1] |
Type(s) of Resistant Mechanism of This Drug
UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
Gastric cancer [ICD-11: 2B72]
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | ||||
Unusual Activation of Pro-survival Pathway (UAPP) | ||||
Key Molecule: Cellular tumor antigen p53 (TP53) | [1] | |||
Molecule Alteration | Missense mutation | p.R282L (c.845G>T) |
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Sensitive Disease | Gastric adenocarcinoma [ICD-11: 2B72.0] | |||
Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | Stomach | N.A. | ||
Experiment for Molecule Alteration |
Immunoblotting analysis | |||
Mechanism Description | The missense mutation p.R282L (c.845G>T) in gene TP53 cause the sensitivity of EAP Protocol by unusual activation of pro-survival pathway | |||
Key Molecule: Cellular tumor antigen p53 (TP53) | [1] | |||
Molecule Alteration | Missense mutation | p.R175H (c.524G>A) |
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Sensitive Disease | Gastric adenocarcinoma [ICD-11: 2B72.0] | |||
Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | Stomach | N.A. | ||
Experiment for Molecule Alteration |
Immunoblotting analysis | |||
Mechanism Description | The missense mutation p.R175H (c.524G>A) in gene TP53 cause the sensitivity of EAP Protocol by unusual activation of pro-survival pathway | |||
Key Molecule: Cellular tumor antigen p53 (TP53) | [1] | |||
Molecule Alteration | Missense mutation | p.R213P (c.638G>C) |
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Sensitive Disease | Gastric adenocarcinoma [ICD-11: 2B72.0] | |||
Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | Stomach | N.A. | ||
Experiment for Molecule Alteration |
Immunoblotting analysis | |||
Mechanism Description | The missense mutation p.R213P (c.638G>C) in gene TP53 cause the sensitivity of EAP Protocol by unusual activation of pro-survival pathway |
References
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