Drug Information

Drug (ID: DG01903) and It's Reported Resistant Information
Name
YW3-56
Synonyms
YW3-56
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Target . NOUNIPROTAC [1]
Type(s) of Resistant Mechanism of This Drug
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
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Breast cancer [ICD-11: 2C60]
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R280K (c.839G>A)
 Molecule Info 
Sensitive Disease ER negative breast cancer [ICD-11: 2C60.7]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model MDA-MB-231 cells Breast Homo sapiens (Human) CVCL_0062
1833TR cells N.A. . N.A.
In Vivo Model Female xenograft nude mouse model Mus musculus
Experiment for
Molecule Alteration		 Western blotting analysis
References
Ref 1 ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer CellsMol Cancer Ther. 2015 Apr;14(4):877-88. doi: 10.1158/1535-7163.MCT-14-1093-T. Epub 2015 Jan 22.

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