Drug Information

Drug (ID: DG01882) and It's Reported Resistant Information

Name	IDH1 inhibitors
Synonyms	IDH1 inhibitors Click to Show/Hide
Target	.	NOUNIPROTAC	[1]

Type(s) of Resistant Mechanism of This Drug

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Click to Show/Hide the Resistance Disease of This Class

Brain cancer [ICD-11: 2A00]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)			Click to Show/Hide
Key Molecule: Oxalosuccinate decarboxylase (IDH1)				[1]
Molecule Alteration	Missense mutation		p.R132H (c.395G>A)	Molecule Info
Sensitive Disease	Brain glioma [ICD-11: 2A00.0]			Disease Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	TS676 cells	Brain	Homo sapiens (Human)	CVCL_A5HX
	TS603 cells	Brain	Homo sapiens (Human)	CVCL_A5HW
	TS516 cells	Brain	Homo sapiens (Human)	CVCL_A5HY
In Vivo Model	SCID mouse xenograft model			Mus musculus
Experiment for Drug Resistance	Soft agar assay
Mechanism Description	The missense mutation p.R132H (c.395G>A) in gene IDH1 cause the sensitivity of IDH1 inhibitors by aberration of the drug's therapeutic target

References

Ref 1	An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cellsScience. 2013 May 3;340(6132):626-30. doi: 10.1126/science.1236062. Epub 2013 Apr 4.

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