Drug Information

Drug (ID: DG01878) and It's Reported Resistant Information

• Name: IMG-2005-5
• Synonyms: IMG-2005-5
• Target: .; NOUNIPROTAC; [1]

Type(s) of Resistant Mechanism of This Drug

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Mature B-cell neoplasms/lymphoma [ICD-11: 2A85]

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: Myeloid differentiation primary response protein MyD88 (MYD88) [1]

• Molecule Alteration: Missense mutation; p.L265P (c.794T>C)
• Sensitive Disease: Mantle cell lymphoma [ICD-11: 2A85.0]
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Blood; N.A.
• Experiment for Molecule Alteration: DNA sequencing assay
• Mechanism Description: The missense mutation p.L265P (c.794T>C) in gene MYD88 cause the sensitivity of IMG-2005-5 by unusual activation of pro-survival pathway

References

• Ref 1: MYD88 L265P somatic mutation in Waldenstr m's macroglobulinemiaN Engl J Med. 2012 Aug 30;367(9):826-33. doi: 10.1056/NEJMoa1200710.