Drug Information

Drug (ID: DG01875) and It's Reported Resistant Information
Name
PW12
Synonyms
PW12
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Target . NOUNIPROTAC [1]
Type(s) of Resistant Mechanism of This Drug
  RTDM: Regulation by the Disease Microenvironment
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
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Cervical cancer [ICD-11: 2C77]
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Regulation by the Disease Microenvironment (RTDM) Click to Show/Hide
Key Molecule: PI3-kinase alpha (PIK3CA) [1]
Molecule Alteration Missense mutation
p.E545K (c.1633G>A)
 Molecule Info 
Sensitive Disease Cervical cancer [ICD-11: 2C77.0]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model Ba/F3 cells Colon Homo sapiens (Human) CVCL_0161
Experiment for
Molecule Alteration		 Immunoblotting analysis
Experiment for
Drug Resistance		 MTS assay
Mechanism Description The missense mutation p.E545K (c.1633G>A) in gene PIK3CA cause the sensitivity of PW12 by aberration of the drug's therapeutic target
References
Ref 1 High levels of p110Delta PI3K expression in solid tumor cells suppress PTEN activity, generating cellular sensitivity to p110 Delta inhibitors through PTEN activationFASEB J. 2012 Jun;26(6):2498-508. doi: 10.1096/fj.11-198192. Epub 2012 Mar 5.

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