Drug Information

Drug (ID: DG01874) and It's Reported Resistant Information
Name
YM-024
Synonyms
YM-024
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Target . NOUNIPROTAC [1]
Type(s) of Resistant Mechanism of This Drug
  UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
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Brain cancer [ICD-11: 2A00]
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Key Molecule: PI3-kinase alpha (PIK3CA) [1]
Molecule Alteration Missense mutation
p.H1047Y (c.3139C>T)
 Molecule Info 
Sensitive Disease FGFR-tacc positive glioblastoma [ICD-11: 2A00.01]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model SK-MG-26 cell N.A. Homo sapiens (Human) CVCL_D701
SK-MG-17 cells N.A. Homo sapiens (Human) CVCL_8574
Experiment for
Molecule Alteration		 Western blotting analysis
Experiment for
Drug Resistance		 CellTiter96 AQueous assay; Soft-agar colony formation assay
References
Ref 1 Targeting class IA PI3K isoforms selectively impairs cell growth, survival, and migration in glioblastomaPLoS One. 2014 Apr 9;9(4):e94132. doi: 10.1371/journal.pone.0094132. eCollection 2014.

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