Drug Information
Drug (ID: DG01870) and It's Reported Resistant Information
| Name |
SHR-A1307
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| Synonyms |
SHR-A1307
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| Target | . | NOUNIPROTAC | [1] | ||
Type(s) of Resistant Mechanism of This Drug
UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
Head and neck cancer [ICD-11: 2D42]
| Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | ||||
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Unusual Activation of Pro-survival Pathway (UAPP)
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| Key Molecule: PI3-kinase alpha (PIK3CA) | [1] | |||
| Molecule Alteration | Missense mutation | p.H1047R (c.3140A>G) |
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| Sensitive Disease | Head and neck squamous cell carcinoma [ICD-11: 2D42.1] | |||
| Experimental Note | Revealed Based on the Cell Line Data | |||
| In Vitro Model | SW480 cells | Colon | Homo sapiens (Human) | CVCL_0546 |
| SW620 cells | Colon | Homo sapiens (Human) | CVCL_0547 | |
| HepG2 cells | Liver | Homo sapiens (Human) | CVCL_0027 | |
| H1975 cells | Lung | Homo sapiens (Human) | CVCL_1511 | |
| HCT116 cells | Colon | Homo sapiens (Human) | CVCL_0291 | |
| LOVO cells | Colon | Homo sapiens (Human) | CVCL_0399 | |
| HCC827 cells | Lung | Homo sapiens (Human) | CVCL_2063 | |
| MCF10A cells | Breast | Homo sapiens (Human) | CVCL_0598 | |
| HT-29 cells | Colon | Homo sapiens (Human) | CVCL_0320 | |
| A431 cells | Skin | Homo sapiens (Human) | CVCL_0037 | |
| DiFi cells | Colon | Homo sapiens (Human) | CVCL_6895 | |
| Detroit562 cells | Pleural effusion | Homo sapiens (Human) | CVCL_1171 | |
| Colo-205 cells | Ascites | Homo sapiens (Human) | CVCL_0218 | |
| In Vivo Model | Female BALB/c nude mouse xenograft model | Mus musculus | ||
| Experiment for Drug Resistance |
CellTiter-Glo assay; IC50 assay | |||
References
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