Drug Information
Drug (ID: DG01852) and It's Reported Resistant Information
Name |
HSP90 inhibitor
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Synonyms |
HSP90 inhibitor
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Target | . | NOUNIPROTAC | [1] |
Type(s) of Resistant Mechanism of This Drug
UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | ||||
Unusual Activation of Pro-survival Pathway (UAPP) | ||||
Key Molecule: Cellular tumor antigen p53 (TP53) | [1] | |||
Molecule Alteration | Missense mutation | p.R248Q (c.743G>A) |
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Sensitive Disease | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | |||
Experimental Note | Revealed Based on the Cell Line Data | |||
In Vitro Model | SkBR3 cells | Breast | Homo sapiens (Human) | CVCL_0033 |
H1975 cells | Lung | Homo sapiens (Human) | CVCL_1511 | |
T47D cells | Breast | Homo sapiens (Human) | CVCL_0553 | |
ES2 cells | Ovary | Homo sapiens (Human) | CVCL_AX39 | |
DU145 cells | Prostate | Homo sapiens (Human) | CVCL_0105 | |
MDA-MB-231 cells | Breast | Homo sapiens (Human) | CVCL_0062 | |
MDA-46 cells | N.A. | Homo sapiens (Human) | N.A. | |
HOC7 cells | Ascites | Homo sapiens (Human) | CVCL_5455 | |
EFO21 cells | Ascites | Homo sapiens (Human) | CVCL_0029 | |
COV434 cells | N.A. | Homo sapiens (Human) | CVCL_2010 | |
COLO704 cells | Ascites | Homo sapiens (Human) | CVCL_1994 | |
HOC7 cells | Ascites | Homo sapiens (Human) | CVCL_5455 | |
In Vivo Model | Athymic (nu/nu) male xenograft mouse model | Mus musculus | ||
Experiment for Molecule Alteration |
Western blotting analysis; Quantitative PCR analysis | |||
Experiment for Drug Resistance |
CellTiter-blue cell viability assay | |||
Key Molecule: Cellular tumor antigen p53 (TP53) | [1] | |||
Molecule Alteration | Missense mutation | p.R175H (c.524G>A) |
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Sensitive Disease | Solid tumour/cancer [ICD-11: 2A00-2F9Z] | |||
Experimental Note | Revealed Based on the Cell Line Data | |||
In Vitro Model | SkBR3 cells | Breast | Homo sapiens (Human) | CVCL_0033 |
H1975 cells | Lung | Homo sapiens (Human) | CVCL_1511 | |
T47D cells | Breast | Homo sapiens (Human) | CVCL_0553 | |
ES2 cells | Ovary | Homo sapiens (Human) | CVCL_AX39 | |
DU145 cells | Prostate | Homo sapiens (Human) | CVCL_0105 | |
MDA-MB-231 cells | Breast | Homo sapiens (Human) | CVCL_0062 | |
MDA-46 cells | N.A. | Homo sapiens (Human) | N.A. | |
HOC7 cells | Ascites | Homo sapiens (Human) | CVCL_5455 | |
EFO21 cells | Ascites | Homo sapiens (Human) | CVCL_0029 | |
COV434 cells | N.A. | Homo sapiens (Human) | CVCL_2010 | |
COLO704 cells | Ascites | Homo sapiens (Human) | CVCL_1994 | |
HOC7 cells | Ascites | Homo sapiens (Human) | CVCL_5455 | |
In Vivo Model | Athymic (nu/nu) male xenograft mouse model | Mus musculus | ||
Experiment for Molecule Alteration |
Western blotting analysis; Quantitative PCR analysis | |||
Experiment for Drug Resistance |
CellTiter-blue cell viability assay |
References
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