Drug (ID: DG01852) and It's Reported Resistant Information
Name
HSP90 inhibitor
Synonyms
HSP90 inhibitor
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Target . NOUNIPROTAC [1]
Type(s) of Resistant Mechanism of This Drug
  UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
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Solid tumour/cancer [ICD-11: 2A00-2F9Z]
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R248Q (c.743G>A)
Sensitive Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model SkBR3 cells Breast Homo sapiens (Human) CVCL_0033
H1975 cells Lung Homo sapiens (Human) CVCL_1511
T47D cells Breast Homo sapiens (Human) CVCL_0553
ES2 cells Ovary Homo sapiens (Human) CVCL_AX39
DU145 cells Prostate Homo sapiens (Human) CVCL_0105
MDA-MB-231 cells Breast Homo sapiens (Human) CVCL_0062
MDA-46 cells N.A. Homo sapiens (Human) N.A.
HOC7 cells Ascites Homo sapiens (Human) CVCL_5455
EFO21 cells Ascites Homo sapiens (Human) CVCL_0029
COV434 cells N.A. Homo sapiens (Human) CVCL_2010
COLO704 cells Ascites Homo sapiens (Human) CVCL_1994
HOC7 cells Ascites Homo sapiens (Human) CVCL_5455
In Vivo Model Athymic (nu/nu) male xenograft mouse model Mus musculus
Experiment for
Molecule Alteration
Western blotting analysis; Quantitative PCR analysis
Experiment for
Drug Resistance
CellTiter-blue cell viability assay
Key Molecule: Cellular tumor antigen p53 (TP53) [1]
Molecule Alteration Missense mutation
p.R175H (c.524G>A)
Sensitive Disease Solid tumour/cancer [ICD-11: 2A00-2F9Z]
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model SkBR3 cells Breast Homo sapiens (Human) CVCL_0033
H1975 cells Lung Homo sapiens (Human) CVCL_1511
T47D cells Breast Homo sapiens (Human) CVCL_0553
ES2 cells Ovary Homo sapiens (Human) CVCL_AX39
DU145 cells Prostate Homo sapiens (Human) CVCL_0105
MDA-MB-231 cells Breast Homo sapiens (Human) CVCL_0062
MDA-46 cells N.A. Homo sapiens (Human) N.A.
HOC7 cells Ascites Homo sapiens (Human) CVCL_5455
EFO21 cells Ascites Homo sapiens (Human) CVCL_0029
COV434 cells N.A. Homo sapiens (Human) CVCL_2010
COLO704 cells Ascites Homo sapiens (Human) CVCL_1994
HOC7 cells Ascites Homo sapiens (Human) CVCL_5455
In Vivo Model Athymic (nu/nu) male xenograft mouse model Mus musculus
Experiment for
Molecule Alteration
Western blotting analysis; Quantitative PCR analysis
Experiment for
Drug Resistance
CellTiter-blue cell viability assay
References
Ref 1 Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatmentNature. 2015 Jul 16;523(7560):352-6. doi: 10.1038/nature14430. Epub 2015 May 25.

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